Hereditary angio-oedema is caused by a heterozygous deficiency of C1 inhibitor. This
inhibitor regulates several inflammatory pathways, and patients with hereditary angio …

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results
in the release of vasoactive kinins (bradykinin-related peptides). This complex system …

Angioedema is defined as localized and self‐limiting edema of the subcutaneous and
submucosal tissue, due to a temporary increase in vascular permeability caused by the …

Background Hereditary angioedema is a disabling, potentially fatal condition caused by
deficiency (type I) or dysfunction (type II) of the C1 inhibitor protein. In a phase 2 trial, the use …

Background Hereditary angioedema is characterized by recurrent attacks of angioedema of
the skin, larynx, and gastrointestinal tract. Bradykinin is the key mediator of symptoms …

Hereditary angioedema (HAE), a rare but life-threatening condition, manifests as acute
attacks of facial, laryngeal, genital, or peripheral swelling or abdominal pain secondary to …

BACKGROUND: There are a limited number of publications on the management of
gynecologic/obstetric events in female patients with hereditary angioedema caused by C1 …

We present a consensus document on the diagnosis and management of C1 inhibitor
deficiency, a syndrome characterized clinically by recurrent episodes of angio-oedema. In …

Abstract Purpose of Review This study aims to examine current knowledge on the
occurrence, pathophysiology, and treatment of angioedema among patients who receive …

Hereditary angioedema type III (HAEIII) is a rare inherited swelling disorder that is
associated with point mutations in the gene encoding the plasma protease factor XII (FXII) …