The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders

S Zhang, X Peng, S Yang, X Li, M Huang, S Wei… - Cell death & …, 2022 - nature.com
Autophagy is a conserved method of quality control in which cytoplasmic contents are
degraded via lysosomes. Lipophagy, a form of selective autophagy and a novel type of lipid …

Lipid droplets in health and disease

G Onal, O Kutlu, D Gozuacik… - Lipids in health and …, 2017 - Springer
Lipids are essential building blocks synthesized by complex molecular pathways and
deposited as lipid droplets (LDs) in cells. LDs are evolutionary conserved organelles found …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Lipid metabolism and lipophagy in cancer

M Maan, JM Peters, M Dutta, AD Patterson - Biochemical and biophysical …, 2018 - Elsevier
The tumor microenvironment can be hypoxic, acidic, and deficient in nutrients, thus causing
the metabolism of tumor cells as well as the neighboring stromal cells to be remodelled to …

[HTML][HTML] Autophagy, lipophagy and lysosomal lipid storage disorders

C Ward, N Martinez-Lopez, EG Otten, B Carroll… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Autophagy is a catabolic process with an essential function in the maintenance of cellular
and tissue homeostasis. It is primarily recognised for its role in the degradation of …

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae

T van Zutphen, V Todde, R de Boer… - Molecular biology of …, 2014 - Am Soc Cell Biol
Cytosolic lipid droplets (LDs) are ubiquitous organelles in prokaryotes and eukaryotes that
play a key role in cellular and organismal lipid homeostasis. Triacylglycerols (TAGs) and …

Autophagy and lipid droplets in the liver

N Martinez-Lopez, R Singh - Annual review of nutrition, 2015 - annualreviews.org
Autophagy is a conserved quality-control pathway that degrades cytoplasmic contents in
lysosomes. Autophagy degrades lipid droplets through a process termed lipophagy …

On the trail of a cereal killer: recent advances in Fusarium graminearum pathogenomics and host resistance

K Kazan, DM Gardiner… - Molecular plant …, 2012 - Wiley Online Library
The ascomycete fungal pathogen Fusarium graminearum (sexual stage: Gibberella zeae)
causes the devastating head blight or scab disease on wheat and barley, and cob or ear rot …

Lipid droplets, lipophagy, and beyond

CW Wang - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2016 - Elsevier
Lipids are essential components for life. Their various structural and physical properties
influence diverse cellular processes and, thereby, human health. Lipids are not genetically …

Regulation and functions of autophagic lipolysis

F Cingolani, MJ Czaja - Trends in Endocrinology & Metabolism, 2016 - cell.com
The selective breakdown by autophagy of lipid droplet (LD)-stored lipids, termed lipophagy,
is a lysosomal lipolytic pathway that complements the actions of cytosolic neutral lipases …