[HTML][HTML] Evolution of blood–brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies

L Han, C Jiang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and
severely limits brain penetration of systemically administered drugs, resulting in ineffective …

A polymer multicellular nanoengager for synergistic NIR‐II photothermal immunotherapy

C Xu, Y Jiang, Y Han, K Pu, R Zhang - Advanced Materials, 2021 - Wiley Online Library
Cell‐membrane‐coated nanoparticles (CCNPs) that integrate the biophysiological
advantages of cell membranes with the multifunctionalities of synthetic materials hold great …

Neutrophil-like cell-membrane-coated nanozyme therapy for ischemic brain damage and long-term neurological functional recovery

L Feng, C Dou, Y Xia, B Li, M Zhao, P Yu, Y Zheng… - ACS …, 2021 - ACS Publications
Oxidative stress and a series of excessive inflammatory responses are major obstacles for
neurological functional recovery after ischemic stroke. Effective noninvasive anti …

The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in …

P Gong, Y Liu, Y Gong, G Chen, X Zhang… - Journal of …, 2021 - Springer
Background and purpose To investigate the association of neutrophil to lymphocyte ratio
(NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) with post …

The predictive role of systemic inflammation response index (SIRI) in the prognosis of stroke patients

Y Zhang, Z Xing, K Zhou, S Jiang - Clinical interventions in aging, 2021 - Taylor & Francis
Purpose Stroke is a disease associated with high mortality. Many inflammatory indicators
such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte …

Recent advances of cell membrane‐coated nanomaterials for biomedical applications

WL Liu, MZ Zou, SY Qin, YJ Cheng… - Advanced Functional …, 2020 - Wiley Online Library
Surface modification of nanomaterials is essential for their biomedical applications owing to
their passive immune clearance and damage to reticuloendothelial systems. Recently, a cell …

Targeted treatment of ischemic stroke by bioactive nanoparticle-derived reactive oxygen species responsive and inflammation-resolving nanotherapies

J Yuan, L Li, Q Yang, H Ran, J Wang, K Hu, W Pu… - ACS …, 2021 - ACS Publications
Stroke is a primary cause of death and disability worldwide, while effective and safe drugs
remain to be developed for its clinical treatment. Herein, we report bioactive nanoparticle …

Highly bioactive zeolitic imidazolate framework-8–capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke

L He, G Huang, H Liu, C Sang, X Liu, T Chen - Science Advances, 2020 - science.org
Rational design of potent antioxidative agent with high biocompatibility is urgently needed to
treat ischemic reperfusion-induced ROS-mediated cerebrovascular and neural injury during …

Neutrophil extracellular traps in homeostasis and disease

H Wang, SJ Kim, Y Lei, S Wang, H Wang… - … and Targeted Therapy, 2024 - nature.com
Neutrophil extracellular traps (NETs), crucial in immune defense mechanisms, are
renowned for their propensity to expel decondensed chromatin embedded with inflammatory …

Engineered nanoerythrocytes alleviate central nervous system inflammation by regulating the polarization of inflammatory microglia

N Yin, Y Zhao, C Liu, Y Yang, ZH Wang… - Advanced …, 2022 - Wiley Online Library
Microglial polarization is one of the most promising therapeutic strategies for multiple central
nervous system (CNS) disorders. However, safe, effective, and controllable microglial …