Heme oxygenase (HO) has been shown to be important for attenuating the overall
production of reactive oxygen species (ROS) through its ability to degrade heme and to …

Adulthood hypertension can be programmed in response to a suboptimal environment in
early life. However, developmental plasticity also implies that one can prevent hypertension …

Low birth weight due to intrauterine growth restriction is associated with various diseases in
adulthood, such as hypertension, cardiovascular disease, insulin resistance and end-stage …

Transient ACE (angiotensin-converting enzyme) inhibition in spontaneously hypertensive
rats is known to protect against future injury-induced cardiac inflammation, fibrosis, and …

Several lines of evidence suggest that the kidney plays an important role in the genesis of
primary hypertension in humans and genetic hypertension in animals. Perhaps the most …

Background: The renal tissue renin-angiotensin system is known to be activated by salt
loading in salt-sensitive rats; however, the response in other organs remains unclear …

Genetic studies in humans and rodent models should help to identify altered genes
important in the development of cardiovascular diseases, such as hypertension. Despite the …

Arterial hypertension is frequently encountered after renal transplantation and is associated
not only with increased cardiovascular complications but also with decreased allograft …

Angiotensin converting enzyme (ACE) inhibitors reduce left ventricular (LV) hypertrophy and
cardiovascular–renal fibrosis. Experimentally, changes in the LV and kidney persist even …

Abstract Angiotensin II (Ang II) is a primary mediator of profibrotic signaling in the heart and
more specifically, the cardiac fibroblast. Ang II-mediated cardiomyocyte hypertrophy in …