In this article, we review the dynamic nature of the filaments (microtubules) that make up the
labile fibers of the mitotic spindle and asters, we discuss the roles that assembly and …

Calmodulin, a protein that binds calcium with high affinity and specificity, is structurally
conserved and functionally preserved throughout the animal and plant kingdoms. It serves …

Progression of the cell cycle and control of apoptosis (programmed cell death) are thought to
be intimately linked processes, acting to preserve homeostasis and developmental …

Tau, a microtubule-associated protein which copurifies with tubulin through successive
cycles of polymerization and depolymerization, has been isolated from tubulin by …

Microtubules can be assembled in vitro from purified α/β tubulin heterodimers in the
presence of GTP. Tubulin is routinely obtained from animal brain tissue through repetitive …

Many eukaryotic cells distribute their intracellular components asymmetrically through
regulated active transport driven by molecular motors along microtubule tracks. While …

This study describes the development and use of a specific method for disassembling
intermediate filament (IF) networks in living cells. It takes advantage of the disruptive effects …

In eukaryotic cells, microtubules, actin, and intermediate filaments interact to form the
cytoskeletal network involved in determination of cell architecture, intracellular transport …

This volume brings together all aspects of TAXOL® research, development, and clinical use.
It provides comprehensive knowledge of the compound and a perspective of the complex …

An association of toxic fungal metabolites, so-called mycotoxins, with human and animal
health has been made since biblical times when ergotism was suspected to be a toxicosis …