A practical review of C-peptide testing in diabetes

E Leighton, CAR Sainsbury, GC Jones - Diabetes therapy, 2017 - Springer
C-peptide is a widely used measure of pancreatic beta cell function. It is produced in
equimolar amounts to endogenous insulin but is excreted at a more constant rate over a …

[HTML][HTML] The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report

R Azziz, E Carmina, D Dewailly… - Fertility and sterility, 2009 - Elsevier
OBJECTIVE: To review all available data and recommend a definition for polycystic ovary
syndrome (PCOS) based on published peer-reviewed data, whether already in use or not, to …

Meal simulation model of the glucose-insulin system

C Dalla Man, RA Rizza, C Cobelli - IEEE Transactions on …, 2007 - ieeexplore.ieee.org
A simulation model of the glucose-insulin system in the postprandial state can be useful in
several circumstances, including testing of glucose sensors, insulin infusion algorithms and …

Sucralose affects glycemic and hormonal responses to an oral glucose load

MY Pepino, CD Tiemann, BW Patterson… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE Nonnutritive sweeteners (NNS), such as sucralose, have been reported to have
metabolic effects in animal models. However, the relevance of these findings to human …

Diabetes: models, signals, and control

C Cobelli, C Dalla Man, G Sparacino… - IEEE reviews in …, 2009 - ieeexplore.ieee.org
The control of diabetes is an interdisciplinary endeavor, which includes a significant
biomedical engineering component, with traditions of success beginning in the early 1960s …

Assessment of pancreatic β-cell function: review of methods and clinical applications

E Cersosimo, C Solis-Herrera… - Current diabetes …, 2014 - ingentaconnect.com
Type 2 diabetes mellitus (T2DM) is characterized by a progressive failure of pancreatic β-
cell function (BCF) with insulin resistance. Once insulin over-secretion can no longer …

C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve β-cell function: report of an ADA workshop, 21–22 October 2001

JP Palmer, GA Fleming, CJ Greenbaum, KC Herold… - Diabetes, 2004 - Am Diabetes Assoc
The underlying cause of type 1 diabetes, loss of β-cell function, has become the therapeutic
target for a number of interventions in patients with type 1 diabetes. Even though insulin …

Diurnal pattern to insulin secretion and insulin action in healthy individuals

A Saad, C Dalla Man, DK Nandy, JA Levine… - Diabetes, 2012 - Am Diabetes Assoc
Evaluation of the existence of a diurnal pattern of glucose tolerance after mixed meals is
important to inform a closed-loop system of treatment for insulin requiring diabetes. We …

Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance

R Basu, E Breda, AL Oberg, CC Powell… - Diabetes, 2003 - Am Diabetes Assoc
Glucose tolerance decreases with age. For determining the cause of this decrease, 67
elderly and 21 young (70.1±0.7 vs. 23.7±0.8 years) participants ingested a mixed meal and …

Feasibility of automating insulin delivery for the treatment of type 1 diabetes

GM Steil, K Rebrin, C Darwin, F Hariri, MF Saad - Diabetes, 2006 - Am Diabetes Assoc
An automated closed-loop insulin delivery system based on subcutaneous glucose sensing
and subcutaneous insulin delivery was evaluated in 10 subjects with type 1 diabetes (2 …