Seven mobile oxazolidinone resistance genes, including cfr, cfr (B), cfr (C), cfr (D), cfr (E),
optrA, and poxtA, have been identified to date. The cfr genes code for 23S rRNA methylases …

The oxazolidinones (linezolid and tedizolid) are last-resort antimicrobial agents used for the
treatment of severe infections in humans caused by MDR Gram-positive bacteria. They bind …

It was once widely held that nearly all reactions in biology were catalyzed via mechanisms
involving paired electron species. Beginning approximately 40 years ago, this paradigm was …

Staphylococcus aureus is a serious human pathogen with remarkable adaptive powers.
Antibiotic-resistant clones rapidly emerge mainly by acquisition of antibiotic-resistance …

Antibiotic resistance continues to plague antimicrobial chemotherapy of infectious disease.
And while true biocide resistance is as yet unrealized, in vitro and in vivo episodes of …

ABSTRACT A novel multidrug resistance phenotype mediated by the Cfr rRNA
methyltransferase is observed in Staphylococcus aureus and Escherichia coli. The cfr gene …

This Minireview summarizes the changes in the field of bacterial resistance to macrolide,
lincosamide, streptogramin, ketolide, and oxazolidinone (MLSKO) antibiotics since the …

ABSTRACT A total of 302 chloramphenicol-resistant Staphylococcus isolates were screened
for the presence of the florfenicol/chloramphenicol resistance genes fexA and cfr and their …

The success of linezolid stimulated significant efforts to discover new agents in the
oxazolidinone class. Over a dozen oxazolidinones have reached the clinic, but many were …

The gene product of cfr from Staphylococcus sciuri confers resistance to chloramphenicol,
florfenicol and clindamycin in Staphylococcus spp. and Escherichia coli. Cfr is not similar to …