The therapeutic importance of acid-base balance
Baking soda and vinegar have been used as home remedies for generations and today we
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …
are only a mouse-click away from claims that baking soda, lemon juice, and apple cider …
An atlas and functional analysis of G-protein coupled receptors in human islets of Langerhans
G-protein coupled receptors (GPCRs) regulate hormone secretion from islets of Langerhans,
and recently developed therapies for type-2 diabetes target islet GLP-1 receptors. However …
and recently developed therapies for type-2 diabetes target islet GLP-1 receptors. However …
Engineering modular, oxygen‐generating microbeads for the in situ mitigation of cellular hypoxia
Insufficient oxygenation is a key obstacle in the design of clinically scalable tissue‐
engineered grafts. In this work, an oxygen‐generating composite material, termed OxySite …
engineered grafts. In this work, an oxygen‐generating composite material, termed OxySite …
Wearable Microneedle Patch for Colorimetric Detection of Multiple Signature Biomarkers in vivo Toward Diabetic Diagnosis
Type 2 diabetes is rapidly emerging as a global public health problem. While blood glucose
monitoring has been the primary method of managing diabetes for decades, the increasing …
monitoring has been the primary method of managing diabetes for decades, the increasing …
Physiological relevance of proton-activated GPCRs
PH Imenez Silva, CA Wagner - Pflügers Archiv-European Journal of …, 2022 - Springer
The detection of H+ concentration variations in the extracellular milieu is accomplished by a
series of specialized and non-specialized pH-sensing mechanisms. The proton-activated G …
series of specialized and non-specialized pH-sensing mechanisms. The proton-activated G …
A static glucose-stimulated insulin secretion (sGSIS) assay that is significantly predictive of time to diabetes reversal in the human islet bioassay
Introduction Static incubation (static glucose-stimulated insulin secretion, sGSIS) is a
measure of islet secretory function. The Stimulation Index (SI; insulin produced in high …
measure of islet secretory function. The Stimulation Index (SI; insulin produced in high …
Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion
T Nakakura, C Mogi, M Tobo, H Tomura, K Sato… - …, 2012 - academic.oup.com
Ovarian cancer G protein-coupled receptor 1 (OGR1) has been shown as a receptor for
protons. In the present study, we aimed to know whether OGR1 plays a role in insulin …
protons. In the present study, we aimed to know whether OGR1 plays a role in insulin …
Naturally-occurring carboxylic acids from traditional antidiabetic plants as potential pancreatic islet FABP3 inhibitors. A molecular docking–aided study
A Hyder - Chemico-Biological Interactions, 2023 - Elsevier
The antidiabetic action of traditional plants is mostly attributed to their antioxidant and anti-
inflammatory properties. These plants are still having some secrets, making them an …
inflammatory properties. These plants are still having some secrets, making them an …
Development and application of an excitation ratiometric optical pH sensor for bioprocess monitoring
The development of a fluorescent excitation ratiometric pH sensor (AHQ‐PEG) using a novel
allylhydroxyquinolinium (AHQ) derivative copolymerized with polyethylene glycol …
allylhydroxyquinolinium (AHQ) derivative copolymerized with polyethylene glycol …
Effect of the immunosuppressive regime of Edmonton protocol on the long-term in vitro insulin secretion from islets of two different species and age categories
A Hyder, C Laue, J Schrezenmeir - Toxicology in vitro, 2005 - Elsevier
The success of the new immunosuppressive regime known as the Edmonton protocol in islet
allotransplantation may suggest that it is also possible that this regime may prevent the …
allotransplantation may suggest that it is also possible that this regime may prevent the …