Tissue, cellular, and molecular level determinants for eye lens stiffness and elasticity
C Cheng - Frontiers in Ophthalmology, 2024 - frontiersin.org
The eye lens is a transparent, ellipsoid tissue in the anterior chamber that is required for the
fine focusing of light onto the retina to transmit a clear image. The focusing function of the …
fine focusing of light onto the retina to transmit a clear image. The focusing function of the …
Unveiling the structural and functional consequences of the p. D109G pathogenic mutation in human αB-Crystallin responsible for restrictive cardiomyopathy and …
MH Jafari, MB Shahsavani, M Hoshino, J Hong… - International Journal of …, 2024 - Elsevier
Abstract αB-Crystallin (αB-Cry) is expressed in many tissues, and mutations in this protein
are linked to various diseases, including cataracts, Alzheimer's disease, Parkinson's …
are linked to various diseases, including cataracts, Alzheimer's disease, Parkinson's …
Binding of βL-Crystallin with Models of Animal and Human Eye Lens-Lipid Membrane
P Hazen, G Trossi-Torres, NK Khadka… - International Journal of …, 2023 - mdpi.com
Several discoveries show that with age and cataract formation, β-crystallin binds with the
lens membrane or associates with other lens proteins, which bind with the fiber cell plasma …
lens membrane or associates with other lens proteins, which bind with the fiber cell plasma …
Insights into the dual nature of αB-crystallin chaperone activity from the p. P39L mutant at the N-terminal region
The substitution of leucine to proline at position 39 (p. P39L) in human αB-crystallin (αB-Cry)
has been associated with conflicting interpretations of pathogenicity in cataracts and …
has been associated with conflicting interpretations of pathogenicity in cataracts and …
Understanding the structural and functional changes and biochemical pathomechanism of the cardiomyopathy-associated p. R123W mutation in human αB-crystallin
Abstract αB-crystallin, a member of the small heat shock protein (sHSP) family, is expressed
in diverse tissues, including the eyes, brain, muscles, and heart. This protein plays a crucial …
in diverse tissues, including the eyes, brain, muscles, and heart. This protein plays a crucial …
Interaction of βL- and γ-Crystallin with Phospholipid Membrane Using Atomic Force Microscopy
NK Khadka, P Hazen, D Haemmerle… - International Journal of …, 2023 - mdpi.com
Highly concentrated lens proteins, mostly β-and γ-crystallin, are responsible for maintaining
the structure and refractivity of the eye lens. However, with aging and cataract formation, β …
the structure and refractivity of the eye lens. However, with aging and cataract formation, β …
[HTML][HTML] Mechanical Properties of Eye Lens Cortical and Nuclear Membranes and the Whole Lens
Purpose: To elucidate the mechanical properties of the bovine lens cortical membrane (CM),
the nuclear membrane (NM) containing cholesterol bilayer domains (CBDs), and whole …
the nuclear membrane (NM) containing cholesterol bilayer domains (CBDs), and whole …