Medical and surgical care of patients with mesothelioma and their relatives carrying germline BAP1 mutations
The most common malignancies that develop in carriers of BAP1 germline mutations include
diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and …
diffuse malignant mesothelioma, uveal and cutaneous melanoma, renal cell carcinoma, and …
Functions of BLM helicase in cells: is it acting like a double-edged sword?
DNA damage repair response is an important biological process involved in maintaining the
fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in …
fidelity of the genome in eukaryotes and prokaryotes. Several proteins that play a key role in …
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial
Mesothelioma is a rare and fatal cancer with limited therapeutic options until the recent
approval of combination immune checkpoint blockade. Here we report the results of the …
approval of combination immune checkpoint blockade. Here we report the results of the …
Germline BARD1 variants predispose to mesothelioma by impairing DNA repair and calcium signaling
We report that~ 1.8% of all mesothelioma patients and 4.9% of those younger than 55, carry
rare germline variants of the BRCA1 associated RING domain 1 (BARD1) gene that were …
rare germline variants of the BRCA1 associated RING domain 1 (BARD1) gene that were …
HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma
JS Suarez, F Novelli, K Goto, M Ehara… - Proceedings of the …, 2023 - National Acad Sciences
Asbestos is the main cause of malignant mesothelioma. Previous studies have linked
asbestos-induced mesothelioma to the release of HMGB1 from the nucleus to the cytoplasm …
asbestos-induced mesothelioma to the release of HMGB1 from the nucleus to the cytoplasm …
Tumor immune microenvironment and genetic alterations in mesothelioma
S Hiltbrunner, L Mannarino, MB Kirschner… - Frontiers in …, 2021 - frontiersin.org
Malignant pleural mesothelioma (MPM) is a rare and fatal disease of the pleural lining. Up to
80% of the MPM cases are linked to asbestos exposure. Even though its use has been …
80% of the MPM cases are linked to asbestos exposure. Even though its use has been …
BAP1 is a novel regulator of HIF-1α
BAP1 is a powerful tumor suppressor gene characterized by haplo insufficiency. Individuals
carrying germline BAP1 mutations often develop mesothelioma, an aggressive malignancy …
carrying germline BAP1 mutations often develop mesothelioma, an aggressive malignancy …
[HTML][HTML] Asbestos-induced chronic inflammation in malignant pleural mesothelioma and related therapeutic approaches—a narrative review
AA Zolondick, G Gaudino, J Xue, HI Pass… - Precision cancer …, 2021 - ncbi.nlm.nih.gov
Objective: The aim of this review is addressing the mechanisms of asbestos carcinogenesis,
including chronic inflammation and autophagy-mediated cell survival, and propose potential …
including chronic inflammation and autophagy-mediated cell survival, and propose potential …
Incidence, mortality and survival in malignant pleural mesothelioma before and after asbestos in Denmark, Finland, Norway and Sweden
K Hemminki, A Försti, T Chen, A Hemminki - BMC cancer, 2021 - Springer
Background Malignant pleural mesothelioma (MPM) is a rare but fatal cancer, which is
largely caused by exposure to asbestos. Reliable information about the incidence of MPM …
largely caused by exposure to asbestos. Reliable information about the incidence of MPM …
Global magnitude and temporal trend of mesothelioma burden along with the contribution of occupational asbestos exposure in 204 countries and territories from …
Y Han, T Zhang, H Chen, X Yang - Critical Reviews in Oncology …, 2022 - Elsevier
Understanding the burden of mesothelioma with the contribution of occupational asbestos
exposure globally provides essential foundations for cancer control, policy decisions and …
exposure globally provides essential foundations for cancer control, policy decisions and …