Visualizing and quantifying antimicrobial drug distribution in tissue
The biodistribution and pharmacokinetics of drugs are vital to the mechanistic understanding
of their efficacy. Measuring antimicrobial drug efficacy has been challenging as plasma drug …
of their efficacy. Measuring antimicrobial drug efficacy has been challenging as plasma drug …
Two-day versus seven-day course of levofloxacin in acute COPD exacerbation: a randomized controlled trial
S Messous, I Trabelsi, K Bel Haj Ali… - Therapeutic …, 2022 - journals.sagepub.com
Introduction: Duration of antibiotic treatment in acute exacerbation of COPD (AECOPD) is
most commonly based on expert opinion. Typical administration periods range from 5 to 7 …
most commonly based on expert opinion. Typical administration periods range from 5 to 7 …
Determination of levofloxacin, ciprofloxacin, moxifloxacin and gemifloxacin in urine and plasma by HPLC–FLD–DAD using pentafluorophenyl core–shell column …
S Yıldırım, HN Karakoç, A Yaşar… - Biomedical …, 2020 - Wiley Online Library
Concentrations of fluoroquinolones, which are used in the treatment of many bacterial
infections, should be monitored in biological fluids as they exhibit concentration‐dependent …
infections, should be monitored in biological fluids as they exhibit concentration‐dependent …
Pharmacokinetic study of ferulic acid following transdermal or intragastric administration in rats
N Yan, Z Tang, Y Xu, X Li, Q Wang - Aaps Pharmscitech, 2020 - Springer
Ferulic acid is contained in some Chinese herbal medicines such as Ligusticum chuanxiong
or Angelica sinensis. Studies have focused on the treatment of inflammatory diseases and …
or Angelica sinensis. Studies have focused on the treatment of inflammatory diseases and …
Reproductive toxicity of enrofloxacin in Caenorhabditis elegans involves oxidative stress-induced cell apoptosis
J Huang, L Liao, G Wang, Z Du, Z Wu - Journal of Environmental Sciences, 2023 - Elsevier
Fluoroquinolone antibiotics (FQs) that persist and bioaccumulate in the environment have
aroused people's great concern. Here, we studied the adverse effects of FQs in soil animals …
aroused people's great concern. Here, we studied the adverse effects of FQs in soil animals …
Comparison of immunochromatographic strips using colloidal gold, quantum dots, and upconversion nanoparticles for visual detection of norfloxacin in milk samples
G Hu, S Gao, X Han, L Yang - Food Analytical Methods, 2020 - Springer
Colloidal gold, quantum dots (QDs), and upconversion nanoparticles (UCNPs), which were
respectively labeled with monoclonal antibody against norfloxacin (NOR), were employed …
respectively labeled with monoclonal antibody against norfloxacin (NOR), were employed …
Which analysis approach is adequate to leverage clinical microdialysis data? A quantitative comparison to investigate exposure and reponse exemplified by …
D Busse, A Schaeftlein, A Solms, L Ilia… - Pharmaceutical …, 2021 - Springer
Purpose Systematic comparison of analysis methods of clinical microdialysis data for impact
on target-site drug exposure and response. Methods 39 individuals received a 500 mg …
on target-site drug exposure and response. Methods 39 individuals received a 500 mg …
Liposomal 5-Fluorouracil Polymer Complexes Facilitate Tumor-Specific Delivery: Pharmaco-Distribution Kinetics Using Microdialysis
W Wang, P Joyce, K Bremmell, R Milne, CA Prestidge - Pharmaceutics, 2022 - mdpi.com
Liposomes are widely used as carriers for anticancer drugs due to their ability to prolong the
retention of encapsulated drugs in blood plasma while directing their distribution …
retention of encapsulated drugs in blood plasma while directing their distribution …
Molecular insights into the aspartate protease Plasmepsin II activity inhibition by fluoroquinolones: A pathway to antimalarial drug development
SF Syed, A Bhattacharya, S Choudhary - International Journal of Biological …, 2025 - Elsevier
Plasmepsin II (PlmII) belongs to the aspartate proteases and is involved in hemoglobin
degradation in Plasmodium falciparum. Due to its critical role in the survival of the …
degradation in Plasmodium falciparum. Due to its critical role in the survival of the …
Synthesis of polyfluoroalkylphosphorylated dihydroquinolines and dihydroisoquinolines decorated with N-acylethenyl substituents by the reaction of bis …
PA Volkov, KO Khrapova, AA Telezhkin… - Journal of Fluorine …, 2023 - Elsevier
Dihydroquinolines and dihydroisoquinolines decorated with 2-or 4-
polyfluoroalkylphosphoryl groups and N-acylethenyl, cyanoethenylphenyl substituents were …
polyfluoroalkylphosphoryl groups and N-acylethenyl, cyanoethenylphenyl substituents were …