Reactive nitrogen species (RNS) and reactive oxygen species (ROS), collectively known as
reactive oxygen and nitrogen species (RONS), are the products of normal cellular …

Elevated levels of NO produced within the central nervous system (CNS) are associated with
the pathogenesis of neuroinflammatory and neurodegenerative human diseases such as …

Glial activation and inflammation coincide with neurofibrillary tangle (NFT) formation in
neurons. However, the mechanism behind the interaction between tau fibrils and glia is …

Although a change in life-style is often the method of first choice for lipid lowering, lipid-
lowering drugs, in general, help to control elevated levels of different forms of lipids in …

Abstract DJ-1 (PARK7) is a neuroprotective protein that protects cells from oxidative stress.
Accordingly, loss-of-function DJ-1 mutations have been linked with a familial form of early …

Lysosomes are ubiquitous membrane-enclosed organelles filled with an acidic interior and
are central to the autophagic, endocytic, or phagocytic pathway. In contrast to its classical …

Juvenile neuronal ceroid lipofuscinosis (JNCL) is a fatal inherited neurodegenerative
disease of children that occurs because of defective function of the lysosomal membrane …

Upon activation, microglia and astrocytes produce a number of proinflammatory molecules
that participate in the pathophysiology of several neurodegenerative disorders. This study …

This study investigated the effects of the selective peroxisome proliferator-activated receptor-
α (PPAR-α) agonist WY14643 on ischemia/reperfusion (I/R) injury in the rat hippocampus …

Amla (Emblica officinalis Gaertn.) is widely used in Indian medicine for the treatment of
various diseases. We have investigated the effects of amla on the lipid metabolism and …