In silico protein interaction screening uncovers DONSON's role in replication initiation
CDC45-MCM2-7-GINS (CMG) helicase assembly is the central event in eukaryotic
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …
replication initiation. In yeast, a multi-subunit “pre-loading complex”(pre-LC) accompanies …
RAD51 bypasses the CMG helicase to promote replication fork reversal
Replication fork reversal safeguards genome integrity as a replication stress response. DNA
translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown …
translocases and the RAD51 recombinase catalyze reversal. However, it remains unknown …
Ligand-induced degrons for studying nuclear functions
MT Kanemaki - Current Opinion in Cell Biology, 2022 - Elsevier
Conditional control of protein expression facilitates studies of nuclear functions, which are
highly dynamic and tightly linked to the cell cycle in proliferating cells. However, conditional …
highly dynamic and tightly linked to the cell cycle in proliferating cells. However, conditional …
High-throughput Oligopaint screen identifies druggable 3D genome regulators
The human genome functions as a three-dimensional chromatin polymer, driven by a
complex collection of chromosome interactions,–. Although the molecular rules governing …
complex collection of chromosome interactions,–. Although the molecular rules governing …
EWSR1 maintains centromere identity
The centromere is essential for ensuring high-fidelity transmission of chromosomes. CENP-
A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere …
A, the centromeric histone H3 variant, is thought to be the epigenetic mark of centromere …
MCMBP promotes the assembly of the MCM2–7 hetero-hexamer to ensure robust DNA replication in human cells
Abstract The MCM2–7 hetero-hexamer is the replicative DNA helicase that plays a central
role in eukaryotic DNA replication. In proliferating cells, the expression level of the MCM2–7 …
role in eukaryotic DNA replication. In proliferating cells, the expression level of the MCM2–7 …
Targeted Protein Degradation Systems: Controlling Protein Stability Using E3 Ubiquitin Ligases in Eukaryotic Species
Y Ogawa, TP Ueda, K Obara, K Nishimura, T Kamura - Cells, 2024 - mdpi.com
This review explores various methods for modulating protein stability to achieve target
protein degradation, which is a crucial aspect in the study of biological processes and drug …
protein degradation, which is a crucial aspect in the study of biological processes and drug …
[PDF][PDF] In silico protein interaction screening uncovers DONSON's role in vertebrate CMG helicase assembly
Y Lim, L Tamayo-Orrego, E Schmid, Z Tarnauskaite… - Science, 2023 - research.ed.ac.uk
CMG (Cdc45-MCM2-7-GINS) helicase assembly is the central event in eukaryotic replication
initiation. In yeast, a multi-subunit “pre-Loading Complex”(pre-LC) accompanies GINS to …
initiation. In yeast, a multi-subunit “pre-Loading Complex”(pre-LC) accompanies GINS to …
TBC9, an essential TBC-domain protein, regulates early vesicular transport and IMC formation in Toxoplasma gondii
M Sun, T Tang, K He, S Long - Communications Biology, 2024 - nature.com
Apicomplexan parasites harbor a complex endomembrane system as well as unique
secretory organelles. These complex cellular structures require an elaborate vesicle …
secretory organelles. These complex cellular structures require an elaborate vesicle …
Characterizing replisome disassembly in human cells
RM Jones, JH Ruiz, S Scaramuzza, S Nath, C Liu… - iScience, 2024 - cell.com
To ensure timely duplication of the entire eukaryotic genome, thousands of replication
machineries (replisomes) act on genomic DNA at any time during S phase. In the final …
machineries (replisomes) act on genomic DNA at any time during S phase. In the final …