Molecular mechanisms of Sanguinarine in cancer prevention and treatment

A Ullah, N Ullah, T Nawaz, T Aziz - Anti-Cancer Agents in …, 2023 - ingentaconnect.com
Historically, natural plant-derived drugs received a great impact of consideration in the
treatment of several human-associated disorders. Cancer is a devastating disease and the …

Metronomic chemotherapy: anti-tumor pathways and combination with immune checkpoint inhibitors

E Muraro, L Vinante, E Fratta, A Bearz, D Höfler… - Cancers, 2023 - mdpi.com
Simple Summary Metronomic chemotherapy, a continuous administration of a lowered dose
of drugs without long breaks, is currently considered an alternative approach for the …

Anti-proliferative and pro-apoptotic effects of digested aglianico grape pomace extract in human colorectal cancer cells

GR Caponio, M Cofano, T Lippolis, I Gigante… - Molecules, 2022 - mdpi.com
Grape pomace (GP)—the major by-product of winemaking processes—still contains
bioactive molecules with known beneficial properties for human health, such as an …

The role of hypoxia-inducible factor-1 alpha in renal disease

H Liu, Y Li, J Xiong - Molecules, 2022 - mdpi.com
Partial pressure of oxygen (pO2) in the kidney is maintained at a relatively stable level by a
unique and complex functional interplay between renal blood flow, glomerular filtration rate …

Resistance to gemcitabine in pancreatic ductal adenocarcinoma: A physiopathologic and pharmacologic review

T Koltai, SJ Reshkin, TMA Carvalho, D Di Molfetta… - Cancers, 2022 - mdpi.com
Simple Summary PDAC is one of the most malignant tumors and its treatment, whether
surgery or chemotherapy, has shown poor results. Resistance to gemcitabine and other …

Schwann cell-derived CXCL2 contributes to cancer pain by modulating macrophage infiltration in a mouse breast cancer model

Y Zhang, R Sang, J Bao, Z Jiang, D Qian… - Brain, Behavior, and …, 2023 - Elsevier
Pain is one of the most severe complications affecting the quality of life of cancer patients.
Although substantial progress has been made in the diagnosis and treatment of cancer, the …

Lead/drug discovery from natural resources

Z Xu, B Eichler, EA Klausner, J Duffy-Matzner, W Zheng - Molecules, 2022 - mdpi.com
Natural products and their derivatives have been shown to be effective drug candidates
against various diseases for many years. Over a long period of time, nature has produced an …

JI017 Induces cell autophagy and apoptosis via elevated levels of reactive oxygen species in human lung cancer cells

JM Ku, MJ Kim, YJ Choi, SY Lee, JY Im, YK Jo… - International Journal of …, 2023 - mdpi.com
Lung cancer is one of the most common malignant tumors and a leading cause of cancer-
related death in the worldwide. Various anticancer drugs, such as cisplatin and pemetrexed …

Exosome-transmitted S100A4 induces immunosuppression and non-small cell lung cancer development by activating STAT3

X Wu, H Zhang, G Jiang, M Peng, C Li… - Clinical and …, 2022 - academic.oup.com
Non-small cell lung cancer (NSCLC) is the primary reason of tumor morbidity and mortality
worldwide. We aimed to study the transfer process of S100A4 between cells and whether it …

The use of breath analysis in the management of lung cancer: is it ready for primetime?

RJ Keogh, JC Riches - Current Oncology, 2022 - mdpi.com
Breath analysis is a promising non-invasive method for the detection and management of
lung cancer. Exhaled breath contains a complex mixture of volatile and non-volatile organic …