[HTML][HTML] Tau PET imaging in neurodegenerative tauopathies—still a challenge
The accumulation of pathological misfolded tau is a feature common to a collective of
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
neurodegenerative disorders known as tauopathies, of which Alzheimer's disease (AD) is …
Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions
VL Villemagne, V Doré, SC Burnham… - Nature Reviews …, 2018 - nature.com
Most neurodegenerative disorders are associated with aggregated protein deposits. In the
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …
case of Alzheimer disease (AD), extracellular amyloid-β (Aβ) aggregates and intracellular …
[HTML][HTML] Multipronged diagnostic and therapeutic strategies for Alzheimer's disease
M Ramesh, T Govindaraju - Chemical science, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …
[HTML][HTML] Discovery and preclinical characterization of [18F]PI-2620, a next-generation tau PET tracer for the assessment of tau pathology in Alzheimer's disease and …
H Kroth, F Oden, J Molette, H Schieferstein… - European journal of …, 2019 - Springer
Purpose Tau deposition is a key pathological feature of Alzheimer's disease (AD) and other
neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined …
neurodegenerative disorders. The spreading of tau neurofibrillary tangles across defined …
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia
MJ Pontecorvo, MD Devous, I Kennedy, M Navitsky… - Brain, 2019 - academic.oup.com
The advent of tau-targeted PET tracers such as flortaucipir (18F)(flortaucipir, also known as
18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of …
18F-AV-1451 or 18F-T807) have made it possible to investigate the sequence of …
Tau PET imaging in neurodegenerative disorders
C Groot, S Villeneuve, R Smith… - Journal of Nuclear …, 2022 - Soc Nuclear Med
The advent of PET ligands that bind tau pathology has enabled the quantification and
visualization of tau pathology in aging and in Alzheimer disease (AD). There is strong …
visualization of tau pathology in aging and in Alzheimer disease (AD). There is strong …
[HTML][HTML] A closer look at amyloid ligands, and what they tell us about protein aggregates
TS Chisholm, CA Hunter - Chemical Society Reviews, 2024 - pubs.rsc.org
The accumulation of amyloid fibrils is characteristic of neurodegenerative diseases such as
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …
Alzheimer's disease (AD) and Parkinson's disease. Detecting these fibrils with fluorescent or …
The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects
R Smith, O Strandberg, N Mattsson-Carlgren, A Leuzy… - Brain, 2020 - academic.oup.com
The development of tau-PET allows paired helical filament tau pathology to be visualized in
vivo. Increased knowledge about conditions affecting the rate of tau accumulation could …
vivo. Increased knowledge about conditions affecting the rate of tau accumulation could …
[HTML][HTML] PET neuroimaging of Alzheimer's disease: radiotracers and their utility in clinical research
W Bao, F Xie, C Zuo, Y Guan… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's Disease (AD), the leading cause of senile dementia, is a progressive
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …
neurodegenerative disorder affecting millions of people worldwide and exerting tremendous …
[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer's disease
S Sanabria Bohórquez, J Marik, A Ogasawara… - European journal of …, 2019 - Springer
Abstract Objective Neurofibrillary tangles (NFTs), consisting of intracellular aggregates of the
tau protein, are a pathological hallmark of Alzheimer's disease (AD). Here we report the …
tau protein, are a pathological hallmark of Alzheimer's disease (AD). Here we report the …