Wearable and implantable devices for cardiovascular healthcare: from monitoring to therapy based on flexible and stretchable electronics

YJ Hong, H Jeong, KW Cho, N Lu… - Advanced Functional …, 2019 - Wiley Online Library
Cardiovascular disease is the leading cause of death and has dramatically increased in
recent years. Continuous cardiac monitoring is particularly important for early diagnosis and …

Injectable alginate hydrogels for cell delivery in tissue engineering

SJ Bidarra, CC Barrias, PL Granja - Acta biomaterialia, 2014 - Elsevier
Alginate hydrogels are extremely versatile and adaptable biomaterials, with great potential
for use in biomedical applications. Their extracellular matrix-like features have been key …

Epicardial FSTL1 reconstitution regenerates the adult mammalian heart

K Wei, V Serpooshan, C Hurtado, M Diez-Cunado… - Nature, 2015 - nature.com
The elucidation of factors that activate the regeneration of the adult mammalian heart is of
major scientific and therapeutic importance. Here we found that epicardial cells contain a …

Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: a review

M Tallawi, E Rosellini, N Barbani… - Journal of the …, 2015 - royalsocietypublishing.org
The development of biomaterials for cardiac tissue engineering (CTE) is challenging,
primarily owing to the requirement of achieving a surface with favourable characteristics that …

Cardiac fibrosis: potential therapeutic targets

S Park, NB Nguyen, A Pezhouman, R Ardehali - Translational Research, 2019 - Elsevier
Cardiovascular disease is a leading cause of mortality in the world and is exacerbated by
the presence of cardiac fibrosis, defined by the accumulation of noncontractile extracellular …

Engineering the regenerative microenvironment with biomaterials

JJ Rice, MM Martino, L De Laporte… - Advanced …, 2013 - Wiley Online Library
Modern synthetic biomaterials are being designed to integrate bioactive ligands within
hydrogel scaffolds for cells to respond and assimilate within the matrix. These advanced …

Detachable microneedle patches deliver mesenchymal stromal cell factor-loaded nanoparticles for cardiac repair

S Hu, D Zhu, Z Li, K Cheng - ACS nano, 2022 - ACS Publications
Intramyocardial injection is a direct and efficient approach to deliver therapeutics to the
heart. However, the injected volume must be very limited, and there is injury to the injection …

Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

N Jalilinejad, M Rabiee, N Baheiraei… - Bioengineering & …, 2023 - Wiley Online Library
A proper self‐regenerating capability is lacking in human cardiac tissue which along with the
alarming rate of deaths associated with cardiovascular disorders makes tissue engineering …

Biomaterials in myocardial tissue engineering

LA Reis, LLY Chiu, N Feric, L Fu… - Journal of tissue …, 2016 - Wiley Online Library
Cardiovascular disease is the leading cause of death in the developed world, and as such
there is a pressing need for treatment options. Cardiac tissue engineering emerged from the …

[HTML][HTML] Drug and cell delivery for cardiac regeneration

CL Hastings, ET Roche, E Ruiz-Hernandez… - Advanced drug delivery …, 2015 - Elsevier
The spectrum of ischaemic cardiomyopathy, encompassing acute myocardial infarction to
congestive heart failure is a significant clinical issue in the modern era. This group of …