Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …

The emergence of form and function during mammalian embryogenesis is a complex
process that involves multiple regulatory levels. The foundations of the body plan are laid …

Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of
developmental potency and are characterized by their ability to generate all cell types of an …

Cerebral organoids provide an accessible system for investigations of cellular composition,
interactions, and organization but have lacked oligodendrocytes, the myelinating glia of the …

Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and
can be preserved in vitro in a naive inner-cell-mass-like configuration by providing …

The earliest aspects of human embryogenesis remain mysterious. To model patterning
events in the human embryo, we used colonies of human embryonic stem cells (hESCs) …

Although the first mouse embryonic stem (ES) cell lines were derived 25 years ago, using
feeder-layer-based blastocyst cultures, subsequent efforts to extend the approach to other …

The complexity of organogenesis hinders in vitro generation of organs derived from a
patient's pluripotent stem cells (PSCs), an ultimate goal of regenerative medicine. Mouse …

Understanding human pre-implantation development has important implications for assisted
reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies …

Human induced pluripotent stem cells (iPSCs) present exciting opportunities for studying
development and for in vitro disease modeling. However, reported variability in the behavior …