Cognitive function represents a complex neurophysiological capacity of the human brain,
encompassing a higher level of neural processing and integration. It is widely …

Disturbances of lipid homeostasis in cells provoke human diseases. The elucidation of the
underlying mechanisms and the development of efficient therapies represent formidable …

Niemann-Pick type C disease is a rare neurodegenerative disorder mainly caused by
mutations in NPC1, resulting in abnormal late endosomal/lysosomal lipid storage. Although …

Background Medulloblastoma (MB) is a malignant tumour of the cerebellum which can be
classified into four major subgroups based on gene expression and genomic features …

The conserved mesencephalic astrocyte-derived neurotrophic factor (MANF) is known for
protecting dopaminergic neurons and functioning in various other tissues. Previously, we …

Rift Valley fever virus (RVFV) is a highly pathogenic mosquito-borne virus capable of
causing hepatitis, encephalitis, blindness, hemorrhagic syndrome, and death in humans and …

The intracellular cholesterol transporter NPC1 functions in late endosomes and lysosomes
to efflux unesterified cholesterol, and its deficiency causes Niemann–Pick disease Type C …

Simple Summary Ferroptosis is a recently defined form of regulatory cell death. To get a
grasp of the prospective role of ferroptosis in the brain development, we collated ferroptosis …

Biomedical research aims to understand the molecular mechanisms causing human
diseases and to develop curative therapies. So far, these goals have been achieved for a …

GM1 gangliosidosis is a lysosomal storage disorder characterized by the accumulation of
GM1 ganglioside, leading to severe neurodegeneration and early mortality. The disease …