Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Apoptosis, a type of programmed cell death that plays a key role in both healthy and
pathological conditions, releases extracellular vesicles such as apoptotic bodies and …

Inflammatory processes are firmly established as central to the development and
complications of cardiovascular diseases. Elevated levels of inflammatory markers have …

In the final stages of apoptosis, apoptotic cells can generate a variety of membrane-bound
vesicles known as apoptotic extracellular vesicles (ApoEVs). Apoptotic bodies (ApoBDs), a …

Discovered in the late 1980s as an extracellular vesicle of endosomal origin secreted from
reticulocytes, exosomes recently gained scientific attention due to its role in intercellular …

Regulated cell death has essential functions in development and in adult tissue
homeostasis. Necroptosis is a newly discovered pathway of regulated necrosis that requires …

When apoptotic cells are not cleared in an efficient and timely manner, they progress to
secondary necrosis and lose their membrane integrity. This results in a leakage of …

Rho-associated coiled-coil containing kinases (ROCK) were originally identified as effectors
of the RhoA small GTPase.–They belong to the AGC family of serine/threonine kinases and …

Histones are intra-nuclear cationic proteins that are present in all eukaryotic cells and are
highly conserved across species. Within the nucleus, they provide structural stability to …

Extracellular Vesicles (EVs) have received considerable attention in recent years, both as
mediators of intercellular communication pathways that lead to tumor progression, and as …