The accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER
stress, resulting in activation of the unfolded protein response (UPR) that aims to restore …

Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

Cancer cells are commonly subjected to endoplasmic reticulum (ER) stress. To gain survival
advantage, cancer cells exploit the adaptive aspects of the unfolded protein response such …

The endoplasmic reticulum (ER) acts as a moving organelle with many important cellular
functions. As the ER lacks sufficient nutrients under pathological conditions leading to …

Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions
while simultaneously inhibiting the development of anti-tumor immune responses. Hostile …

Melanoma is an aggressive malignancy originating from pigment-producing melanocytes.
The development of targeted therapies (MAPK pathway inhibitors) and immunotherapies …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Cancers remain a major public health problem worldwide, which still require profound
research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are …

The current Coronavirus global pandemic necessitates the search for novel targets and
therapeutic avenues. Shaban et al. 1 reported the use of an endoplasmic reticulum (ER) …

The unfolded protein response (UPR) is an adaptive cellular program used by eukaryotic
cells to cope with protein misfolding stress. During tumor development, cancer cells are …