Antiretroviral therapy is not curative. Given the challenges in providing lifelong therapy to a
global population of more than 35 million people living with HIV, there is intense interest in …

Today HIV infection cannot be cured due to the presence of a reservoir of latently infected
cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is …

A latent reservoir for HIV-1 in resting CD4+ T lymphocytes precludes cure. Mechanisms
underlying reservoir stability are unclear. Recent studies suggest an unexpected degree of …

Antiretroviral therapy fails to cure HIV-1 infection because latent proviruses persist in resting
CD4+ T cells. T cell activation reverses latency, but< 1% of proviruses are induced to …

Despite antiretroviral therapy, HIV-1 persists in memory CD4+ T cells, creating a barrier to
cure. The majority of HIV-1 proviruses are defective and considered clinically irrelevant …

Highly active antiretroviral therapy (HAART) suppresses HIV-1 replication but cannot
eliminate the virus because HIV-1 establishes latent infection. Interruption of HAART leads …

The possibility of HIV-1 eradication has been limited by the existence of latently infected
cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have …

Given the limitations of antiretroviral therapy and recent advances in our understanding of
HIV persistence during effective treatment, there is a growing recognition that a cure for HIV …

The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …

Effective antiretroviral therapy (ART) blunts viraemia, which enables HIV-1-infected
individuals to control infection and live long, productive lives. However, HIV-1 infection …