Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity
enables them to regulate a remarkable range of physiologic and pathologic responses. To …

Redox state constitutes an important background of numerous liver disorders. The redox
state participates in the course of inflammatory, metabolic and proliferative liver diseases …

A hallmark of pancreatic tumors is their highly desmoplastic stroma composed of fibroblasts,
immune cells, and a dense network of collagen fibers. Tumor-associated macrophages are …

Silybum marianum or milk thistle (MT) is the most well‐researched plant in the treatment of
liver disease. The active complex of MT is a lipophilic extract from the seeds of the plant and …

Transforming growth factor β (TGF-β) is the most potent and ubiquitous profibrogenic
cytokine, and its expression is increased in almost all the fibrotic diseases and in …

Diets high in saturated fat and fructose have been implicated in the development of obesity
and nonalcoholic steatohepatitis (NASH) in humans. We hypothesized that mice exposed to …

Fibrosis is a chronic and progressive process characterized by an excessive accumulation
of extracellular matrix (ECM) leading to stiffening and/or scarring of the involved tissue …

Reactive oxygen species (ROS) play a key role in chronic liver injury and fibrosis. Homologs
of NADPH oxidases (NOXs) are major sources of ROS, but the exact role of the individual …

Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic
liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins …

Intestinal fibrosis is a major complication of the inflammatory bowel diseases (IBD) and
although inflammation is necessary for its development, it would appear that it plays a minor …