From progenitors to progeny: shaping striatal circuit development and function
R Knowles, N Dehorter, T Ellender - Journal of Neuroscience, 2021 - Soc Neuroscience
Understanding how neurons of the striatum are formed and integrate into complex synaptic
circuits is essential to provide insight into striatal function in health and disease. In this …
circuits is essential to provide insight into striatal function in health and disease. In this …
Radial glia in the ventral telencephalon
M Turrero García, CC Harwell - FEBS letters, 2017 - Wiley Online Library
The ventral telencephalon is the developmental origin of the basal ganglia and the source of
neuronal and glial cells that integrate into developing circuits in other areas of the brain …
neuronal and glial cells that integrate into developing circuits in other areas of the brain …
Striatal neurons directly converted from Huntington's disease patient fibroblasts recapitulate age-associated disease phenotypes
In Huntington's disease (HD), expansion of CAG codons in the huntingtin gene (HTT) leads
to the aberrant formation of protein aggregates and the differential degeneration of striatal …
to the aberrant formation of protein aggregates and the differential degeneration of striatal …
[HTML][HTML] Continuous and discrete neuron types of the adult murine striatum
The mammalian striatum is involved in many complex behaviors and yet is composed
largely of a single neuron class: the spiny projection neuron (SPN). It is unclear to what …
largely of a single neuron class: the spiny projection neuron (SPN). It is unclear to what …
The coding and long noncoding single-cell atlas of the developing human fetal striatum
INTRODUCTION The striatum modulates distinct characteristics of human social behavior
and is an area affected in many neurological diseases. We created a comprehensive single …
and is an area affected in many neurological diseases. We created a comprehensive single …
Dlx1/2-dependent expression of Meis2 promotes neuronal fate determination in the mammalian striatum
Z Su, Z Wang, S Lindtner, L Yang, Z Shang… - …, 2022 - journals.biologists.com
The striatum is a central regulator of behavior and motor function through the actions of D1
and D2 medium-sized spiny neurons (MSNs), which arise from a common lateral ganglionic …
and D2 medium-sized spiny neurons (MSNs), which arise from a common lateral ganglionic …
Cortical neural stem cell lineage progression is regulated by extrinsic signaling molecule sonic hedgehog
Neural stem cells (NSCs) in the prenatal neocortex progressively generate different
subtypes of glutamatergic projection neurons. Following that, NSCs have a major switch in …
subtypes of glutamatergic projection neurons. Following that, NSCs have a major switch in …
Radial glial lineage progression and differential intermediate progenitor amplification underlie striatal compartments and circuit organization
The circuitry of the striatum is characterized by two organizational plans: the division into
striosome and matrix compartments, thought to mediate evaluation and action, and the direct …
striosome and matrix compartments, thought to mediate evaluation and action, and the direct …
DNA methylation in huntington's disease
N Zsindely, F Siági, L Bodai - International Journal of Molecular Sciences, 2021 - mdpi.com
Methylation of cytosine in CpG dinucleotides is the major DNA modification in mammalian
cells that is a key component of stable epigenetic marks. This modification, which on the one …
cells that is a key component of stable epigenetic marks. This modification, which on the one …
Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects
E Montalban, A Giralt, L Taing, EHS Schut… - Molecular …, 2022 - nature.com
Forebrain dopamine-sensitive (dopaminoceptive) neurons play a key role in movement,
action selection, motivation, and working memory. Their activity is altered in Parkinson's …
action selection, motivation, and working memory. Their activity is altered in Parkinson's …