A TRAF-like E3 ubiquitin ligase TrafE coordinates ESCRT and autophagy in endolysosomal damage response and cell-autonomous immunity to Mycobacterium …

L Raykov, M Mottet, J Nitschke, T Soldati - Elife, 2023 - elifesciences.org
Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that
induce plasma membrane or endolysosomal compartments damage. This severe stress is …

[HTML][HTML] Polycystins recruit cargo to distinct ciliary extracellular vesicle subtypes

IA Nikonorova, KC Jacobs, J Saul, JD Walsh, J Wang… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Therapeutic use of tiny extracellular vesicles (EVs) requires understanding cargo loading
mechanisms. Here, we used a modular proximity label approach to identify EV cargo …

The Dictyostelium discoideum E3 ubiquitin ligase TrafE coordinates endolysosomal damage response and cell-autonomous immunity to Mycobacterium marinum

L Raykov, M Mottet, J Nitschke, T Soldati - BioRxiv, 2021 - biorxiv.org
Cells are perpetually challenged by pathogens, protein aggregates or chemicals, that
induce plasma membrane or endolysosomal compartments damage. Endolysosomal …

TRAF inhibition drives cancer cell apoptosis and improves retinoic acid sensitivity in multiple cancers models

K Zhong, X Liu, W Ding, L Peng, X Zeng, Y Gu - Discover Oncology, 2023 - Springer
TNF receptor-associated factors (TRAFs) are signaling adaptor proteins that play a crucial
role in regulating cellular receptors' signaling transduction to downstream pathways and …

The effects of methylglyoxal, a metabolite derived from glycolysis, on metabolic responses of adipocytes

SP Ng - 2023 - repository.kulib.kyoto-u.ac.jp
Conclusion This study aimed on elucidating the effects of the MG on adipocyte function.
Adipocytes play a huge role in systemic glucose and lipid metabolism, and these metabolic …