Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

Persistent bacterial infections and persister cells

RA Fisher, B Gollan, S Helaine - Nature Reviews Microbiology, 2017 - nature.com
Many bacteria can infect and persist inside their hosts for long periods of time. This can be
due to immunosuppression of the host, immune evasion by the pathogen and/or ineffective …

Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

Y Huang, L Mu, X Zhao, Y Han, B Guo - ACS nano, 2022 - ACS Publications
Burns are a common health problem worldwide and are highly susceptible to bacterial
infections that are difficult to handle with ordinary wound dressings. Therefore, burn wound …

Recent advances in design of antimicrobial peptides and polypeptides toward clinical translation

Y Jiang, Y Chen, Z Song, Z Tan, J Cheng - Advanced Drug Delivery …, 2021 - Elsevier
The recent outbreaks of infectious diseases caused by multidrug-resistant pathogens have
sounded a piercing alarm for the need of new effective antimicrobial agents to guard public …

[HTML][HTML] Therapeutic strategies against bacterial biofilms

Y Bi, G Xia, C Shi, J Wan, L Liu, Y Chen, Y Wu… - Fundamental …, 2021 - Elsevier
The emergence of multi-drug resistance makes bacterial infection a major threat to public
health and economy. The formation of bacterial biofilms is one of the main reasons of …

Formation, physiology, ecology, evolution and clinical importance of bacterial persisters

B Van den Bergh, M Fauvart… - FEMS microbiology …, 2017 - academic.oup.com
Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Host defense antimicrobial peptides as antibiotics: design and application strategies

B Mishra, S Reiling, D Zarena, G Wang - Current opinion in chemical …, 2017 - Elsevier
Highlights•Antibiotic resistance is a serious problem of our era.•Antimicrobial peptides are
important templates for developing new antibiotics.•Both peptide discovery and application …

Bacterial heterogeneity and antibiotic survival: understanding and combatting persistence and heteroresistance

L Dewachter, M Fauvart, J Michiels - Molecular cell, 2019 - cell.com
For decades, mankind has dominated the battle against bacteria, yet the tide is slowly
turning. Our antibacterial strategies are becoming less effective, allowing bacteria to get the …

Fighting bacterial persistence: Current and emerging anti-persister strategies and therapeutics

V Defraine, M Fauvart, J Michiels - Drug Resistance Updates, 2018 - Elsevier
In addition to the well-known strategies of antibiotic resistance and biofilm formation,
bacterial populations possess an additional survival strategy to endure hostile environments …

Strategies and progresses for enhancing targeted antibiotic delivery

A Nazli, DL He, D Liao, MZI Khan, C Huang… - Advanced drug delivery …, 2022 - Elsevier
Antibiotic resistance is a global health issue and a potential risk for society. Antibiotics
administered through conventional formulations are devoid of targeting effect and often …