Chalcone derivatives: anti-inflammatory potential and molecular targets perspectives
Chalcone or (E)-1, 3-diphenyl-2-propene-1-one scaffold has gained considerable scientific
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …
interest in medicinal chemistry owing to its simple chemistry, ease in synthesizing a variety …
QSAR-driven design, synthesis and discovery of potent chalcone derivatives with antitubercular activity
New anti-tuberculosis (anti-TB) drugs are urgently needed to battle drug-resistant
Mycobacterium tuberculosis strains and to shorten the current 6–12-month treatment …
Mycobacterium tuberculosis strains and to shorten the current 6–12-month treatment …
Synthesis of a series of novel dihydroartemisinin monomers and dimers containing chalcone as a linker and their anticancer activity
A new series of monomer and dimer derivatives of dihydroartemisinin (DHA) containing
substituted chalcones as a linker were synthesized and investigated for their cytotoxicity in …
substituted chalcones as a linker were synthesized and investigated for their cytotoxicity in …
Synthesis and evaluation of chalcone derivatives as inhibitors of neutrophils' chemotaxis, phagocytosis and production of reactive oxygen species
SNA Bukhari, Y Tajuddin, VJ Benedict… - Chemical biology & …, 2014 - Wiley Online Library
Inhibitory effects on neutrophils' chemotaxis, phagocytosis and production of reactive
oxygen species (ROS) are among the important targets in developing anti‐inflammatory …
oxygen species (ROS) are among the important targets in developing anti‐inflammatory …
Computer-aided discovery of two novel chalcone-like compounds active and selective against Leishmania infantum
MN Gomes, LM Alcântara, BJ Neves… - Bioorganic & medicinal …, 2017 - Elsevier
Leishmaniasis are infectious diseases caused by parasites of genus Leishmania that affect
affects 12 million people in 98 countries mainly in Africa, Asia, and Latin America. Effective …
affects 12 million people in 98 countries mainly in Africa, Asia, and Latin America. Effective …
In vitro and in vivo synergistic interaction of substituted chalcone derivatives with norfloxacin against methicillin resistant Staphylococcus aureus
Thirty chalcone derivatives were synthesized via a base catalyzed Claisen Schmidt
condensation and evaluated for their anti-methicillin-resistant Staphylococcus aureus …
condensation and evaluated for their anti-methicillin-resistant Staphylococcus aureus …
Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors
A series of forty-five 1, 5-diphenylpenta-2, 4-dien-1-one analogues were synthesized and
evaluated for their nitric oxide (NO) inhibition activity in IFN-γ/LPS-activated RAW 264.7 …
evaluated for their nitric oxide (NO) inhibition activity in IFN-γ/LPS-activated RAW 264.7 …
Antinociceptive Effect of 3-(2, 3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one in Mice Models of Induced Nociception
The antinociceptive effects produced by intraperitoneal administration of a novel synthetic
chalcone, 3-(2, 3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one (DMFP), were …
chalcone, 3-(2, 3-dimethoxyphenyl)-1-(5-methylfuran-2-yl) prop-2-en-1-one (DMFP), were …
Inhibition of nitric oxide and prostaglandin E2 production by pyrrolylated-chalcones: Synthesis, biological activity, crystal structure analysis, and molecular docking …
In search of potent anti-inflammatory agents, twenty-four chalcone derivatives including
seven new compounds (13–17, 21 and 23) containing pyrrole moiety were designed …
seven new compounds (13–17, 21 and 23) containing pyrrole moiety were designed …
Inhibition of Epithelial CC‐Family Chemokine Synthesis by the Synthetic Chalcone DMPF‐1 via Disruption of NF‐κB Nuclear Translocation and Suppression of …
Asthma is associated with increased pulmonary inflammation and airway
hyperresponsiveness. The interaction between airway epithelium and inflammatory …
hyperresponsiveness. The interaction between airway epithelium and inflammatory …