The lysosomal degradation pathway of autophagy plays a fundamental role in cellular,
tissue, and organismal homeostasis and is mediated by evolutionarily conserved autophagy …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here …

Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their
homologs in other organisms have enabled researchers to investigate physiological …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Abstract Knowledge gained over the past 10 years about the mechanisms that underpin
autophagy has provided a universal framework for studies of diverse physiological and …

Autophagy, once viewed exclusively as a cytoplasmic auto-digestive process, has its less
intuitive but biologically distinct non-degradative roles. One manifestation of these functions …

Reactive oxygen and nitrogen species change cellular responses through diverse
mechanisms that are now being defined. At low levels, they are signalling molecules, and at …

Mycobacterium tuberculosis, a major global health threat, replicates in macrophages in part
by inhibiting phagosome–lysosome fusion, until interferon-γ (IFNγ) activates the …

Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of
fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid …