From structure to function: Route to understanding lncRNA mechanism
J Graf, M Kretz - BioEssays, 2020 - Wiley Online Library
RNAs have emerged as a major target for diagnostics and therapeutics approaches.
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
Regulatory nonprotein‐coding RNAs (ncRNAs) in particular display remarkable versatility …
The molecular structure of long non-coding RNAs: emerging patterns and functional implications
Long non-coding RNAs (lncRNAs) are recently-discovered transcripts that regulate vital
cellular processes and are crucially connected to diseases. Despite their unprecedented …
cellular processes and are crucially connected to diseases. Despite their unprecedented …
Targeting Xist with compounds that disrupt RNA structure and X inactivation
Although more than 98% of the human genome is non-coding, nearly all of the drugs on the
market target one of about 700 disease-related proteins. The historical reluctance to invest …
market target one of about 700 disease-related proteins. The historical reluctance to invest …
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy
The current pandemic situation caused by the Betacoronavirus SARS-CoV-2 (SCoV2)
highlights the need for coordinated research to combat COVID-19. A particularly important …
highlights the need for coordinated research to combat COVID-19. A particularly important …
Conserved pseudoknots in lncRNA MEG3 are essential for stimulation of the p53 pathway
T Uroda, E Anastasakou, A Rossi, JM Teulon… - Molecular cell, 2019 - cell.com
Long non-coding RNAs (lncRNAs) are key regulatory molecules, but unlike with other RNAs,
the direct link between their tertiary structure motifs and their function has proven elusive …
the direct link between their tertiary structure motifs and their function has proven elusive …
RNA-based coacervates as a model for membraneless organelles: formation, properties, and interfacial liposome assembly
Liquid–liquid phase separation is responsible for formation of P granules, nucleoli, and
other membraneless subcellular organelles composed of RNA and proteins. Efforts to …
other membraneless subcellular organelles composed of RNA and proteins. Efforts to …
[HTML][HTML] Jpx RNA regulates CTCF anchor site selection and formation of chromosome loops
Chromosome loops shift dynamically during development, homeostasis, and disease.
CCCTC-binding factor (CTCF) is known to anchor loops and construct 3D genomes, but how …
CCCTC-binding factor (CTCF) is known to anchor loops and construct 3D genomes, but how …
A rapid RIG-I signaling relay mediates efficient antiviral response
RIG-I is essential for host defense against viral pathogens, as it triggers the release of type I
interferons upon encounter with viral RNA molecules. In this study, we show that RIG-I is …
interferons upon encounter with viral RNA molecules. In this study, we show that RIG-I is …
Targeting RNA with small molecules: identification of selective, RNA-binding small molecules occupying drug-like chemical space
NF Rizvi, JP Santa Maria Jr, A Nahvi… - … the Science of Drug …, 2020 - journals.sagepub.com
Although the potential value of RNA as a target for new small molecule therapeutics is
becoming increasingly credible, the physicochemical properties required for small …
becoming increasingly credible, the physicochemical properties required for small …
Function by structure: spotlights on Xist long non-coding RNA
G Pintacuda, AN Young, A Cerase - Frontiers in molecular …, 2017 - frontiersin.org
Recent experimental evidence indicates that lncRNAs can act as regulatory molecules in the
context of development and disease. Xist, the master regulator of X chromosome …
context of development and disease. Xist, the master regulator of X chromosome …