BACKGROUND The defining feature of eukaryotic cells is the presence of membrane-bound
organelles of diverse kinds, each with specialized functions. Most organelles have multiple …

The endoplasmic reticulum (ER) is the largest organelle in the cell, and its functions have
been studied for decades. The past several years have provided novel insights into the …

Regions of close apposition between two organelles, often referred to as membrane contact
sites (MCSs), mostly form between the endoplasmic reticulum and a second organelle …

Membrane contact sites between mitochondria and other organelles are important for lipid
and ion exchange, membrane dynamics, and signaling. Recent advances are revealing …

Organelle contact sites perform fundamental functions in cells, including lipid and ion
homeostasis, membrane dynamics, and signaling. Using a forward proteomics approach in …

The endoplasmic reticulum–mitochondria encounter structure (ERMES) complex tethers the
endoplasmic reticulum and the mitochondria. It is thought to facilitate interorganelle lipid …

Mitochondria are complex organelles with two membranes. Their architecture is determined
by characteristic folds of the inner membrane, termed cristae. Recent studies in yeast and …

Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the
behavior of mitochondria inside eukaryotic cells has changed dramatically, and the …

Membrane contact sites between endoplasmic reticulum (ER) and mitochondria, mediated
by the ER–mitochondria encounter structure (ERMES) complex, are critical for mitochondrial …

The distinct activities of organelles depend on the proper function of their membranes.
Coordinated membrane biogenesis of different organelles necessitates lipid transport from …