Targeting ferroptosis against ischemia/reperfusion cardiac injury

J Lillo-Moya, C Rojas-Solé, D Muñoz-Salamanca… - Antioxidants, 2021 - mdpi.com
Ischemic heart disease is a leading cause of death worldwide. Primarily, ischemia causes
decreased oxygen supply, resulting in damage of the cardiac tissue. Naturally …

Ischemia-induced ACSL4 activation contributes to ferroptosis-mediated tissue injury in intestinal ischemia/reperfusion

Y Li, D Feng, Z Wang, Y Zhao, R Sun, D Tian… - Cell Death & …, 2019 - nature.com
Ferroptosis is a recently identified form of regulated cell death defined by the iron-dependent
accumulation of lipid reactive oxygen species. Ferroptosis has been studied in various …

[HTML][HTML] How much ischemia can the liver tolerate during resection?

WG van Riel, RF van Golen, MJ Reiniers… - … surgery and nutrition, 2016 - ncbi.nlm.nih.gov
The use of vascular inflow occlusion (VIO, also known as the Pringle maneuver) during liver
surgery prevents severe blood loss and the need for blood transfusion. The most commonly …

Liproxstatin-1 Alleviates Lung Transplantation-induced Cold Ischemia–Reperfusion Injury by Inhibiting Ferroptosis

J Zhao, J Li, D Wei, F Gao, X Yang, B Yue… - …, 2023 - journals.lww.com
Background. Primary graft dysfunction, which is directly related to cold ischemia–reperfusion
(CI/R) injury, is a major obstacle in lung transplantation (LTx). Ferroptosis, a novel mode of …

[HTML][HTML] The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion

RF van Golen, MJ Reiniers, G Marsman… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Objective and background Activation of sterile inflammation after hepatic
ischemia/reperfusion (I/R) culminates in liver injury. The route to liver damage starts with …

Succinate accumulation and ischemia–reperfusion injury: of mice but not men, a study in renal ischemia–reperfusion

LGM Wijermars, AF Schaapherder… - American Journal of …, 2016 - Wiley Online Library
A recent seminal paper implicated ischemia‐related succinate accumulation followed by
succinate‐driven reactive oxygen species formation as a key driver of ischemia–reperfusion …

Inhibiting cardiac mitochondrial fatty acid oxidation attenuates myocardial injury in a rat model of cardiac arrest

P Wang, F Zhang, L Pan, Y Tan, F Song… - Oxidative Medicine …, 2021 - Wiley Online Library
Mitochondrial fatty acid oxidation (FAO) is involved in myocardial damage after
cardiopulmonary resuscitation (CPR). This study is aimed at investigating the effect of …

[HTML][HTML] Neuropathic pain releasing calcitonin gene related peptide protects against stroke in rats

Y Wang, Z Liu, X Ge, X Hu, X Cao, L Li… - American Journal of …, 2020 - ncbi.nlm.nih.gov
Neuropathic pain (NPP) is deemed as a potential risk of stroke; however, recent pieces of
evidence showed that calcitonin gene-related peptide is involving in pain progression as …

Reactive oxygen and nitrogen species and liver ischemia-reperfusion injury: role of lipoic acid

FTE Alban, D Gyamfi, RF van Golen, M Heger - The Liver, 2018 - Elsevier
Lipoic acid (LA) constitutes a promising antioxidant that reduces the pathological
consequences of liver ischemia/reperfusion (I/R). LA is an endogenous nonenzymatic …

Carotid chemoreceptor denervation does not impair hypoxia-induced thermal downregulation but vitiates recovery from a hypothermic and hypometabolic state in …

SD Hemelrijk, TM van Gulik, M Heger - Scientific reports, 2019 - nature.com
Induction of hypothermia and consequent hypometabolism by pharmacological
downmodulation of the internal thermostat could be protective in various medical situations …