Despite widespread clinical use of antimalarial drugs such as hydroxychloroquine and
chloroquine in the treatment of rheumatoid arthritis (RA), systemic lupus erythematosus …

Ever present hurdles for the discovery of new drugs for cancer therapy have necessitated
the development of the alternative strategy of drug repurposing, the development of old …

Objective To assess the efficacy and safety of hydroxychloroquine plus standard of care
compared with standard of care alone in adults with coronavirus disease 2019 (covid-19) …

Immune evasion is a major obstacle for cancer treatment. Common mechanisms of evasion
include impaired antigen presentation caused by mutations or loss of heterozygosity of the …

Autophagy is a regulated mechanism that removes unnecessary or dysfunctional cellular
components and recycles metabolic substrates. In response to stress signals in the tumour …

Background Pancreatic cancer continues to be one of the world's most lethal cancers.
Chemotherapy resistance in patients with advanced pancreatic cancer often accompany …

Autophagy is the process by which cells degrade and recycle proteins and organelles to
maintain intracellular homeostasis. Generally, autophagy plays a protective role in cells, but …

Autophagy, a multistep lysosomal degradation pathway that supports nutrient recycling and
metabolic adaptation, has been implicated as a process that regulates cancer. Although …

Collagen is the major component of the tumor microenvironment and participates in cancer
fibrosis. Collagen biosynthesis can be regulated by cancer cells through mutated genes …

Background Pancreatic cancer is one of the most lethal malignancies and has an extremely
poor diagnosis and prognosis. The development of resistance to gemcitabine is still a major …