Antitumour dendritic cell vaccination in a priming and boosting approach
A Harari, M Graciotti, M Bassani-Sternberg… - Nature Reviews Drug …, 2020 - nature.com
Mobilizing antitumour immunity through vaccination potentially constitutes a powerful
anticancer strategy but has not yet provided robust clinical benefits in large patient …
anticancer strategy but has not yet provided robust clinical benefits in large patient …
Tricks with tetramers: how to get the most from multimeric peptide–MHC
L Wooldridge, A Lissina, DK Cole… - …, 2009 - Wiley Online Library
The development of fluorochrome‐conjugated peptide–major histocompatibility complex
(pMHC) multimers in conjunction with continuing advances in flow cytometry has …
(pMHC) multimers in conjunction with continuing advances in flow cytometry has …
The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness
The T-cell receptor (TCR) interacts with peptide-major histocompatibility complexes (pMHC)
to discriminate pathogens from self-antigens and trigger adaptive immune responses. Direct …
to discriminate pathogens from self-antigens and trigger adaptive immune responses. Direct …
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex
T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …
A TCR mechanotransduction signaling loop induces negative selection in the thymus
The T cell antigen receptor (TCR) expressed on thymocytes interacts with self-peptide major
histocompatibility complex (pMHC) ligands to signal apoptosis or survival. Here, we found …
histocompatibility complex (pMHC) ligands to signal apoptosis or survival. Here, we found …
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity
The cross-reactivity of T cells with pathogen-and self-derived peptides has been implicated
as a pathway involved in the development of autoimmunity. However, the mechanisms that …
as a pathway involved in the development of autoimmunity. However, the mechanisms that …
Cooperative binding of T cell receptor and CD4 to peptide-MHC enhances antigen sensitivity
Antigen recognition by the T cell receptor (TCR) of CD4+ T cells can be greatly enhanced by
the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra …
the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra …
CD8 coreceptor engagement of MR1 enhances antigen responsiveness by human MAIT and other MR1-reactive T cells
Mucosal-associated invariant T (MAIT) cells detect microbial infection via recognition of
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …
riboflavin-based antigens presented by the major histocompatibility complex class I (MHC-I) …
Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects
L Klotz, M Eschborn, M Lindner, M Liebmann… - Science Translational …, 2019 - science.org
Interference with immune cell proliferation represents a successful treatment strategy in T
cell–mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis …
cell–mediated autoimmune diseases such as rheumatoid arthritis and multiple sclerosis …
Coreceptors and TCR signaling–the strong and the weak of it
The T-cell coreceptors CD4 and CD8 have well-characterized and essential roles in thymic
development, but how they contribute to immune responses in the periphery is unclear …
development, but how they contribute to immune responses in the periphery is unclear …