Analytical characterization of liposomes and other lipid nanoparticles for drug delivery

Y Fan, M Marioli, K Zhang - Journal of pharmaceutical and biomedical …, 2021 - Elsevier
Lipid nanoparticles, especially liposomes and lipid/nucleic acid complexed nanoparticles
have shown great success in the pharmaceutical industry. Their success is attributed to …

Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

A cyclic ion mobility-mass spectrometry system

K Giles, J Ujma, J Wildgoose, S Pringle… - Analytical …, 2019 - ACS Publications
Improvements in the performance and availability of commercial instrumentation have made
ion mobility-mass spectrometry (IM-MS) an increasingly popular approach for the structural …

Recurrent topics in mass spectrometry-based metabolomics and lipidomics—standardization, coverage, and throughput

E Rampler, YE Abiead, H Schoeny, M Rusz… - Analytical …, 2020 - ACS Publications
We have come a long way in the last years of developing analytical strategies in
metabolomics. We have seen huge progress in tackling multiplatform measurement, data …

Trapped ion mobility spectrometry and PASEF enable in-depth lipidomics from minimal sample amounts

CG Vasilopoulou, K Sulek, AD Brunner… - Nature …, 2020 - nature.com
A comprehensive characterization of the lipidome from limited starting material remains very
challenging. Here we report a high-sensitivity lipidomics workflow based on nanoflow liquid …

Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry

T Xia, F Zhou, D Zhang, X Jin, H Shi, H Yin… - Nature …, 2023 - nature.com
A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …

High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations

DG Delafield, G Lu, CJ Kaminsky, L Li - TrAC Trends in Analytical …, 2022 - Elsevier
Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

High-performance molecular imaging with MALDI trapped ion-mobility time-of-flight (timsTOF) mass spectrometry

JM Spraggins, KV Djambazova, ES Rivera… - Analytical …, 2019 - ACS Publications
Imaging mass spectrometry (IMS) enables the spatially targeted molecular assessment of
biological tissues at cellular resolutions. New developments and technologies are essential …

Four-dimensional trapped ion mobility spectrometry lipidomics for high throughput clinical profiling of human blood samples

R Lerner, D Baker, C Schwitter, S Neuhaus… - Nature …, 2023 - nature.com
Lipidomics encompassing automated lipid extraction, a four-dimensional (4D) feature
selection strategy for confident lipid annotation as well as reproducible and cross-validated …

Recent advances in differentiation of isomers by ion mobility mass spectrometry

Q Wu, JY Wang, DQ Han, ZP Yao - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Differentiation of isomers is an important analytical task in many fields, eg, chemistry,
biology, pharmaceutical science, medicine, environmental science, food science. Ion …