Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family.
Although cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also …

The general view on cysteine cathepsins, which were long believed to be primarily involved
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …

Type I collagen fibers account for 90% of the organic matrix of bone. The degradation of this
collagen is a major event during bone resorption, but its mechanism is unknown. A series of …

Objective Osteoclast differentiation factor (ODF; also known as osteoprotegerin ligand,
receptor activator of nuclear factor κB ligand, and tumor necrosis factor–related activation …

The best established proteolytic event of osteoclasts is bone matrix solubilization by the
cysteine proteinase cathepsin K. Here, however, we draw the attention on osteoclastic …

The binding of growth factors to the extracellular matrix (ECM) may be a key pathway for
regulation of their activity. We have shown that a major mechanism for storage of …

Dendritic cells (DCs), the mononuclear cells that initiate immune response, and osteoclasts,
the multinucleated bone-resorbing cells, are derived from monocyte/macrophage precursor …

Abstract Background Matrix-metalloproteinases 9 (MMP-9) belongs to the class of matrix
metalloproteinases whose main function is to degrade and remodel the extracellular matrix …

Human cathepsin K is a novel cysteine protease previously reported to be restricted in its
expression to osteoclasts. Immunolocalization of cathepsin K in breast tumor bone …

Comprehending the pathogenesis of giant cell tumor of bone (GCT) is of critical importance
for developing novel targeted treatments for this locally-aggressive primary bone tumor. GCT …