Protein folding is one of the fundamental processes in life and therefore needs to be tightly
regulated. Many cellular quality control systems are in place to ensure that proteostasis is …

The current protein folding literature is reviewed. Two main approaches to the problem of
folding were selected for this review: geometrical and biophysical. The geometrical …

Protein fibrillation is traditionally associated with misfolding, loss of functional phenotype,
and gain of toxicity in neurodegenerative diseases. However, many organisms exploit fibrils …

Despite the spectacular success of cutting-edge protein fold prediction methods, many
critical questions remain unanswered, including why proteins can reach their native state in …

The traditional reconstruction of molecular events of the past based on sequence
conservation becomes very vague beyond one to two billion years ago. There are certain …

Abstract Purpose of Review Biomedicine is witnessing a paradigm shift in the way complex
disorders are investigated. In particular, the need for big data interpretation has led to the …

​ Understanding the general laws of an effective system for the transport of substances in
cells is an important goal of systems and synthetic biology and will help us to answer why …

The structure of Escherichia coli chaperonin GroEL was studied using various experimental
tools. Such studies produced information about its structure with increasing details …

Protein structures can be conceptualized as context-aware self-organizing systems. One of
its emerging properties is a modular architecture. Such modular architecture has been …

This chapter outlines applications in genome mining, along with computational methods to
predict protein structure and protein-ligand docking. It offers a simple computational route to …