Preparation of biomolecule-polymer conjugates by grafting-from using ATRP, RAFT, or ROMP

MS Messina, KMM Messina, A Bhattacharya… - Progress in polymer …, 2020 - Elsevier
Biomolecule-polymer conjugates are constructs that take advantage of the functional or
otherwise beneficial traits inherent to biomolecules and combine them with synthetic …

[HTML][HTML] Self-assembly of protein-polymer conjugates for drug delivery

CA Stevens, K Kaur, HA Klok - Advanced drug delivery reviews, 2021 - Elsevier
Protein-polymer conjugates are a class of molecules that combine the stability of polymers
with the diversity, specificity, and functionality of biomolecules. These bioconjugates can …

Protein-polymer bioconjugates via a versatile oxygen tolerant photoinduced controlled radical polymerization approach

A Theodorou, E Liarou, DM Haddleton… - Nature …, 2020 - nature.com
The immense application potential of amphiphilic protein-polymer conjugates remains
largely unexplored, as established “grafting from” synthetic protocols involve time …

Aqueous photoinduced living/controlled polymerization: tailoring for bioconjugation

J Xu, K Jung, NA Corrigan, C Boyer - Chemical Science, 2014 - pubs.rsc.org
We report a photoinduced living polymerization technique able to polymerize a large range
of monomers, including methacrylates, acrylates and acrylamides, in water and biological …

Precision conjugation: An emerging tool for generating protein–polymer conjugates

X Liu, W Gao - Angewandte Chemie International Edition, 2021 - Wiley Online Library
Protein–polymer conjugates are increasingly being applied in biomedicine because of the
unique combination of the biological activity of the proteins and the multifunctionality and …

In situ encapsulation of biologically active ingredients into polymer particles by polymerization in dispersed media

M Lages, J Nicolas - Progress in Polymer Science, 2023 - Elsevier
The encapsulation of biologically active ingredients (eg, peptides, proteins, enzymes, drugs)
into polymer particles is extensively used for drug delivery purposes. However, this strategy …

In situ growth of self-assembled protein–polymer nanovesicles for enhanced intracellular protein delivery

X Liu, W Gao - ACS applied materials & interfaces, 2017 - ACS Publications
We report a new and general method, in situ growth, for designing self-assembled protein–
polymer nanovesicles for intracellular protein delivery. In situ polymerization of a water …

Thermally-labile segmented hyperbranched copolymers: Using reversible-covalent chemistry to investigate the mechanism of self-condensing vinyl copolymerization

H Sun, CP Kabb, BS Sumerlin - Chemical Science, 2014 - pubs.rsc.org
A thermally-reversible inimer was used to confirm the controlled growth of individual
branches during self-condensing vinyl atom transfer radical polymerization (ATRP) …

Rapid Oxygen-Tolerant Synthesis of Protein-Polymer Bioconjugates via Aqueous Copper-Mediated Polymerization

A Theodorou, D Gounaris, E Voutyritsa… - …, 2022 - ACS Publications
The synthesis of protein–polymer conjugates usually requires extensive and costly
deoxygenation procedures, thus limiting their availability and potential applications. In this …

Oxygen tolerant, photoinduced controlled radical polymerization approach for the synthesis of giant amphiphiles

A Theodorou, P Mandriotis, A Anastasaki… - Polymer …, 2021 - pubs.rsc.org
Amphiphilic protein–polymer conjugates form hybrid nanostructures with a broad range of
potential applications. Herein, we expand the scope of amphiphilic protein–polymer …