Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …

Intercalated discs (ICDs) are highly orchestrated structures that connect neighboring
cardiomyocytes in the heart. Three major complexes are distinguished in ICD: desmosome …

Alzheimer's disease (AD) is defined by the presence of abundant amyloid-β (Aβ) and tau
neuropathology. While this neuropathology is necessary for AD diagnosis, it is not sufficient …

Evidence from basic molecular biology has noted a critical role of GSK-3 in Alzheimer's
disease (AD) pathogenesis such as beta-amyloid (Aβ) production and accumulation, the …

As a consequence of the considerable increase in the human lifespan over the last century,
we are experiencing the appearance and impact of new age-related diseases. The causal …

Objective Most neurodegenerative diseases contain hyperphosphorylated Tau [p-Tau]. We
examined for the first time epitopes at which Tau is hyperphosphorylated in Parkinson's …

Alzheimer's disease (AD) is a neurodegenerative brain disorder associated with the loss of
synapses between neurons in the brain. Synaptic cell adhesion molecules are cell surface …

Late-onset sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but its
origin remains poorly understood. The Bmi1/Ring1 protein complex maintains transcriptional …

Alzheimer's disease (AD), the most common neurodegenerative disease and the first cause
of dementia worldwide, has no effective treatment, and its pathological mechanisms are not …