Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

Alzheimer's disease (AD) is a central neurodegenerative disorder characterized by
behavioral disturbance and progressive cognitive impairment, and it is common in pre …

The amyloid beta (Aβ) fibrillar aggregate is the hallmark of Alzheimer's disease (AD).
Disassembling preformed fibril or inhibiting Aβ aggregation is considered as a therapeutic …

The review discusses prospects for the use of fullerenes and their various functionalised
adducts: polyhydroxylated fullerenes (fullerenols), carboxylated fullerenes, adducts with …

Self-assembling peptides and carbon nanomaterials have attracted great interest for their
respective potential to bring innovation in the biomedical field. Combination of these two …

Alzheimer's disease (AD) is associated with the aberrant self-assembly of amyloid-β (Aβ)
protein into fibrillar deposits. The disaggregation of Aβ fibril is believed as one of the major …

Nowadays, determining the disassembly mechanism of amyloids under nanomaterials
action is a crucial issue for their successful future use in therapy of neurodegenerative and …

Central nervous system (CNS) diseases, mainly including neurodegenerative diseases and
psychiatric diseases, have become the leading cause of death and disability in the world …

The formation of amyloid fibrils by α-synuclein (αS) protein inside the Lewy bodies and Lewy
neurites is the prominent pathological hallmark of Parkinson's disease (PD). The fibrillation …

Acetylcholinesterase (AChE) is characterized as a key target for designing inhibitors to
prevent Alzheimer's disease (AD). The binding free energy of a ligand to the AChE enzyme …