Cognition, brain structure, and brain function in individuals with obesity and related disorders

H Tanaka, DD Gourley, M Dekhtyar, AP Haley - Current obesity reports, 2020 - Springer
Abstract Purpose of Review Obesity is one of the most serious public health concerns.
Excess adipose tissue, particularly with a centralized distribution, is associated with …

Higher blood pressure is associated with greater white matter lesions and brain atrophy: a systematic review with meta-analysis

K Alateeq, EI Walsh, N Cherbuin - Journal of clinical medicine, 2021 - mdpi.com
Background: To summarise and quantify the evidence on the association between Blood
pressure (BP), white matter lesions (WMLs), and brain volumes. Method: Electronic …

Association of plasma and CSF cytochrome P450, soluble epoxide hydrolase, and ethanolamide metabolism with Alzheimer's disease

K Borkowski, TL Pedersen, NT Seyfried, JJ Lah… - Alzheimer's research & …, 2021 - Springer
Background Alzheimer's disease, cardiovascular disease, and other cardiometabolic
disorders may share inflammatory origins. Lipid mediators, including oxylipins …

Predictor of cognitive impairment: metabolic syndrome or circadian syndrome

Y Liu, B Zang, J Shao, N Ning, L He, Y Ma - BMC geriatrics, 2023 - Springer
Background It was reported that metabolic syndrome increases the risk for cognitive
impairment and circadian rhythm may influence cognition behavior. Identifying the potential …

[HTML][HTML] Insulin resistance in Alzheimer's disease: The genetics and metabolomics links

AM Amin, H Mostafa, HMJ Khojah - Clinica Chimica Acta, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease with significant socioeconomic
burden worldwide. Although genetics and environmental factors play a role, AD is highly …

Metabolic syndrome‐related cognitive impairment with white matter hyperintensities and functional network analysis

W Zheng, X Zhou, J Yin, H Liu, W Yin, W Zhang… - …, 2023 - Wiley Online Library
Objective This study aimed to explore the relationship between white matter hyperintensities
(WMHs) and cognitive impairment related to metabolic syndrome (MetS) and the underlying …

Association of Metabolic Syndrome With Neuroimaging and Cognitive Outcomes in the UK Biobank

D Qureshi, A Topiwala, SU Al Abid, NE Allen… - Diabetes …, 2024 - Am Diabetes Assoc
OBJECTIVE Metabolic syndrome (MetS) has been linked to dementia. In this study, we
examined the association of MetS with neuroimaging and cognition in dementia-free adults …

Serum metabolomic biomarkers of perceptual speed in cognitively normal and mildly impaired subjects with fasting state stratification

K Borkowski, AY Taha, TL Pedersen, PL De Jager… - Scientific Reports, 2021 - nature.com
Cognitive decline is associated with both normal aging and early pathologies leading to
dementia. Here we used quantitative profiling of metabolites involved in the regulation of …

The orbitofrontal cortex functionally links obesity and white matter hyperintensities

B Park, K Byeon, MJ Lee, SH Kim, H Park - Scientific Reports, 2020 - nature.com
Many studies have linked dysfunction in cognitive control-related brain regions with obesity
and the burden of white matter hyperintensities (WMHs). This study aimed to explore how …

Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study

I Frentz, S Marcolini, CCI Schneider, MA Ikram… - The Journal of …, 2024 - Springer
Background Metabolic syndrome is associated with increased risk of dementia. Yet, findings
on how longitudinal development of metabolic syndrome status affects cognition remain …