Advances in the development of new tuberculosis drugs and treatment regimens
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid,
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …
Clofazimine for the treatment of tuberculosis
JAM Stadler, G Maartens, G Meintjes… - Frontiers in …, 2023 - frontiersin.org
Shorter (6–9 months), fully oral regimens containing new and repurposed drugs are now the
first-choice option for the treatment of drug-resistant tuberculosis (DR-TB). Clofazimine, long …
first-choice option for the treatment of drug-resistant tuberculosis (DR-TB). Clofazimine, long …
Mechanisms of action and therapeutic efficacies of the lipophilic antimycobacterial agents clofazimine and bedaquiline
Abstract Drug-resistant (DR)-TB is the major challenge confronting the global TB control
programme, necessitating treatment with second-line anti-TB drugs, often with limited …
programme, necessitating treatment with second-line anti-TB drugs, often with limited …
Engineered drug delivery devices to address Global Health challenges
There is a dire need for innovative solutions to address global health needs. Polymeric
systems have been shown to provide substantial benefit to all sectors of healthcare …
systems have been shown to provide substantial benefit to all sectors of healthcare …
Potential of dry powder inhalers for tuberculosis therapy: facts, fidelity and future
Tuberculosis (TB) is a contagious and airborne infectious disease caused by the pathogen
Mycobacterium tuberculosis (Mtb). In spite of substantial research efforts, continuous …
Mycobacterium tuberculosis (Mtb). In spite of substantial research efforts, continuous …
Dry powder inhalable formulations for anti-tubercular therapy
Tuberculosis (TB) is an intracellular infectious disease caused by the airborne bacterium,
Mycobacterium tuberculosis. Despite considerable research efforts, the treatment of TB …
Mycobacterium tuberculosis. Despite considerable research efforts, the treatment of TB …
Inhaled drug treatment for tuberculosis: Past progress and future prospects
AJ Hickey, PG Durham, A Dharmadhikari… - Journal of Controlled …, 2016 - Elsevier
Since the 1990s the rising incidence of multiple drug resistant TB, particularly in the context
of human immunodeficiency virus co-infected patients, has threatened global TB control. At …
of human immunodeficiency virus co-infected patients, has threatened global TB control. At …
Clofazimine nanoclusters show high efficacy in experimental TB with amelioration in paradoxical lung inflammation
The rise of tuberculosis (TB) superbugs has impeded efforts to control this infectious ailment,
and new treatment options are few. Paradoxical Inflammation (PI) is another major problem …
and new treatment options are few. Paradoxical Inflammation (PI) is another major problem …
[HTML][HTML] Clofazimine inhalation suspension for the aerosol treatment of pulmonary nontuberculous mycobacterial infections
B Banaschewski, D Verma, LJ Pennings… - Journal of Cystic …, 2019 - Elsevier
Background Nontuberculous mycobacteria are recognized as a concern for cystic fibrosis
(CF) patients due to increasing disease prevalence and the potential for detrimental effects …
(CF) patients due to increasing disease prevalence and the potential for detrimental effects …
[HTML][HTML] Preparation and characterization of beta-glucan particles containing a payload of nanoembedded rifabutin for enhanced targeted delivery to macrophages
TK Upadhyay, N Fatima, D Sharma… - EXCLI …, 2017 - ncbi.nlm.nih.gov
Abstract β-glucan particles (GP) are polymeric carbohydrates, mainly found as components
of cell wall fungi, yeast, bacteria and also in cereals such as barley and oat, and have been …
of cell wall fungi, yeast, bacteria and also in cereals such as barley and oat, and have been …