Leveraging pleiotropy for the improved treatment of psychiatric disorders
DJ Woodward, JG Thorp, CM Middeldorp… - Molecular …, 2024 - nature.com
Over 90% of drug candidates fail in clinical trials, while it takes 10–15 years and one billion
US dollars to develop a single successful drug. Drug development is more challenging for …
US dollars to develop a single successful drug. Drug development is more challenging for …
GWAShug: a comprehensive platform for decoding the shared genetic basis between complex traits based on summary statistics
The shared genetic basis offers very valuable insights into the etiology, diagnosis and
therapy of complex traits. However, a comprehensive resource providing shared genetic …
therapy of complex traits. However, a comprehensive resource providing shared genetic …
Splicing-specific transcriptome-wide association uncovers genetic mechanisms for schizophrenia
Recent studies have highlighted the essential role of RNA splicing, a key mechanism of
alternative RNA processing, in establishing connections between genetic variations and …
alternative RNA processing, in establishing connections between genetic variations and …
Fine-mapping causal tissues and genes at disease-associated loci
Complex diseases often have distinct mechanisms spanning multiple tissues. We propose
tissue–gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for …
tissue–gene fine-mapping (TGFM), which infers the posterior inclusion probability (PIP) for …
Inferring causal direction between two traits using R2 with application to transcriptome-wide association studies
In Mendelian randomization, two single SNP-trait correlation-based methods have been
developed to infer the causal direction between an exposure (eg, a gene) and an outcome …
developed to infer the causal direction between an exposure (eg, a gene) and an outcome …
Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer
Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their
utility for prostate cancer (PCa) screening. Using genome-wide association study (GWAS) …
utility for prostate cancer (PCa) screening. Using genome-wide association study (GWAS) …
[HTML][HTML] A scoping review of statistical methods to investigate colocalization between genetic associations and microRNA expression in osteoarthritis
K Zang, M Brossard, T Wilson, SA Ali… - … and Cartilage Open, 2024 - Elsevier
Background Genetic colocalization analysis is a statistical method that evaluates whether
genetic association signals (ie, loci identified in genome-wide association studies [GWAS]) …
genetic association signals (ie, loci identified in genome-wide association studies [GWAS]) …
regionalpcs improve discovery of DNA methylation associations with complex traits
We have developed the regionalpcs method, an approach for summarizing gene-level
methylation. regionalpcs addresses the challenge of deciphering complex epigenetic …
methylation. regionalpcs addresses the challenge of deciphering complex epigenetic …
webTWAS 2.0: update platform for identifying complex disease susceptibility genes through transcriptome-wide association study
Transcriptome-wide association study (TWAS) has successfully identified numerous
complex disease susceptibility genes in the post-genome-wide association study (GWAS) …
complex disease susceptibility genes in the post-genome-wide association study (GWAS) …
Multivariate proteome-wide association study to identify causal proteins for Alzheimer disease
Alzheimer disease (AD) is a complex and progressive neurodegenerative disorder that
accounts for the majority of individuals with dementia. Here, we aim to identify causal …
accounts for the majority of individuals with dementia. Here, we aim to identify causal …