DNA methylation is of paramount importance for mammalian embryonic development. DNA
methylation has numerous functions: it is implicated in the repression of transposons and …

Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset
of genes, is required for normal development, and its disruption leads to human disease …

DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …

DNA methylation (5-methylcytosine, 5mC) is a major form of DNA modification in the
mammalian genome that plays critical roles in chromatin structure and gene expression. In …

Periconceptional diet may persistently influence DNA methylation levels with phenotypic
consequences. However, a comprehensive assessment of the characteristics of prenatal …

The oocyte epigenome plays critical roles in mammalian gametogenesis and
embryogenesis. Yet, how it is established remains elusive. Here, we report that histone …

Genomic imprinting affects a subset of genes in mammals and results in a monoallelic,
parental-specific expression pattern. Most of these genes are located in clusters that are …

Cytosine DNA methylation is a stable epigenetic mark that is crucial for diverse biological
processes, including gene and transposon silencing, imprinting and X chromosome …

The term epigenetics was first used to refer to the complex interactions between the genome
and the environment that are involved in development and differentiation in higher …

X chromosome inactivation and genomic imprinting are classic epigenetic processes that
cause disease when not appropriately regulated in mammals. Whereas X chromosome …