Optimization of therapeutic antibodies for reduced self-association and non-specific binding via interpretable machine learning
Antibody development, delivery, and efficacy are influenced by antibody-antigen affinity
interactions, off-target interactions that reduce antibody bioavailability and …
interactions, off-target interactions that reduce antibody bioavailability and …
Development of a pan‐tau multivalent nanobody that binds tau aggregation motifs and recognizes pathological tau aggregates
N McArthur, B Kang… - Biotechnology …, 2024 - Wiley Online Library
Alzheimer's disease and other tauopathies are characterized by the misfolding and
aggregation of the tau protein into oligomeric and fibrillar structures. Antibodies against tau …
aggregation of the tau protein into oligomeric and fibrillar structures. Antibodies against tau …
Flow cytometric isolation of drug-like conformational antibodies specific for amyloid fibrils
AA Desai, JM Zupancic, H Trzeciakiewicz, JE Gerson… - bioRxiv, 2023 - biorxiv.org
Antibodies that recognize specific protein conformational states are broadly important for
research, diagnostic and therapeutic applications, yet they are difficult to generate in a …
research, diagnostic and therapeutic applications, yet they are difficult to generate in a …
Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates
JM Zupancic, MD Smith, H Trzeciakiewicz… - Frontiers in …, 2023 - frontiersin.org
Single-domain antibodies, also known as nanobodies, are broadly important for studying the
structure and conformational states of several classes of proteins, including membrane …
structure and conformational states of several classes of proteins, including membrane …