Despite the major improvement in therapeutic management of thalassemia major, iron
overload is considered a challenging conundrum in these patients and heart disease still …

Beta-thalassemia (BTH), a recessively inherited haemoglobin (Hb) disorder, causes iron
overload (IO), extra-medullary haematopoiesis and bone marrow expansion with major …

Objectives: Beta-thalassemias are a group of recessively autosomal inherited disorders of
hemoglobin synthesis, which, due to mutations of the beta-globin gene, lead to various …

Purpose Transfusion-dependent beta-thalassemia (TDT) patients suffer from various
endocrinopathies. The main contributing factor associated with these complications is iron …

Objectives We sought to assess the complications and challenges facing the management
of β-thalassemia major (β-TM) in Iraq. Methods A total of 150 consecutive patients with β-TM …

Methods: All β-TM patients registered in the day care of Sultan Qaboos University Hospital
were included in this retrospective study. Results: There were 187 patients with β-TM with a …

Thalassemia is a genetic disease caused by disruption of globin chain synthesis leading to
severe anemia and thus regular blood transfusion is necessary. However, there have been …

As a cause of chronic blood transfusions, iron overload is an important issue in β-
thalassemia (β-thal) patients that leads to multiple organ dysfunctions. This is an updated …

Introduction Management of transfusion‐dependent thalassemia (TDT) can be challenging
due to numerous potential disease‐related complications and comorbidities in particular …

Introduction: Frequent blood transfusions results in iron overload and lead to multiple
endocrine complications. In spite of improvements in iron chelation therapy, a significant …