Involvement of astrocytes in Alzheimer's disease from a neuroinflammatory and oxidative stress perspective

RE González-Reyes, MO Nava-Mesa… - Frontiers in molecular …, 2017 - frontiersin.org
Alzheimer disease (AD) is a frequent and devastating neurodegenerative disease in
humans, but still no curative treatment has been developed. Although many explicative …

Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence

H Hampel, R Nisticò, NT Seyfried, AI Levey… - Ageing Research …, 2021 - Elsevier
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets

RA Neff, M Wang, S Vatansever, L Guo, C Ming… - Science …, 2021 - science.org
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …

Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer's disease: review, recommendation, implementation and application

M Wang, W Song, C Ming, Q Wang, X Zhou… - Molecular …, 2022 - Springer
Alzheimer's disease (AD) is the most common form of dementia, characterized by
progressive cognitive impairment and neurodegeneration. Extensive clinical and genomic …

Amyloid blood biomarker detects Alzheimer's disease

A Nabers, L Perna, J Lange, U Mons… - EMBO molecular …, 2018 - embopress.org
Alzheimer's disease (AD) is currently incurable, but there is general agreement that a
minimally invasive blood biomarker for screening in preclinical stages would be crucial for …

Moving rehabilitation research forward: developing consensus statements for rehabilitation and recovery research

J Bernhardt, K Borschmann, L Boyd… - … journal of stroke, 2016 - journals.sagepub.com
Stroke recovery is the next frontier in stroke medicine. While growth in rehabilitation and
recovery research is exponential, a number of barriers hamper our ability to rapidly progress …

When does Alzheimer′ s disease really start? The role of biomarkers

A Lloret, D Esteve, MA Lloret, A Cervera-Ferri… - International journal of …, 2019 - mdpi.com
While Alzheimer's disease (AD) classical diagnostic criteria rely on clinical data from a
stablished symptomatic disease, newer criteria aim to identify the disease in its earlier …

Alzheimer's disease: biomarkers in the genome, blood, and cerebrospinal fluid

RA Huynh, C Mohan - Frontiers in neurology, 2017 - frontiersin.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that slowly destroys
memory and thinking skills, resulting in behavioral changes. It is estimated that nearly 36 …

Biomarker potential of brain‐secreted extracellular vesicles in blood in Alzheimer's disease

AP Badhwar, AS Haqqani - Alzheimer's & Dementia: Diagnosis …, 2020 - Wiley Online Library
Introduction Brain cells secrete extracellular microvesicles (EVs) that cross the blood‐brain
barrier. Involved in cell‐to‐cell communication, EVs contain surface markers and a …

Neurodegeneration and Alzheimer's disease (AD). What can proteomics tell us about the Alzheimer's brain?

G Moya-Alvarado, N Gershoni-Emek, E Perlson… - Molecular & Cellular …, 2016 - ASBMB
Neurodegenerative diseases, such as Alzheimer′ s diseases (AD), are becoming more
prevalent as the population ages. However, the mechanisms that lead to synapse …