Within the paradigm of the two-signal model of lymphocyte activation, the interest in
costimulation has witnessed a remarkable emergence in the past few years with the …

A complex network of many interacting mechanisms orchestrates immune and inflammatory
responses. Among these, the cation channels of the transient receptor potential (TRP) family …

The adaptive immune response is initiated in secondary lymphoid organs by contact
between antigen-bearing dendritic cells (DCs) and antigen-specific CD4+ T cells. However …

T helper (Th) cell activation is required for the adaptive immune response. Formation of the
immunological synapse (IS) between Th cells and antigen-presenting cells is essential for …

T cell cytoarchitecture differs dramatically depending on whether the cell is circulating within
the bloodstream, migrating through tissues, or interacting with antigen-presenting cells. The …

The onset and regulation of a specific immune response results from communication
between T cells and antigen-presenting cells (APCs), which form molecular interactions at …

We present transmission electron microscope (TEM) evidence that ICC and ICC‐like cells
frequently establish close contacts (synapses) with several types of immunoreactive cells …

Direct cell-cell communication between adjacent cells is vital for the development and
regulation of functional tissues. However, current biological techniques are difficult to scale …

TRP proteins form ion channels which are activated following receptor stimulation. In T-cell
lines, expression data of TRP proteins have been published. However, almost no data about …

Clinical malaria is associated with proliferation of blood-stage parasites. During the blood
stage, Plasmodium parasites invade host red blood cells, multiply, egress and reinvade …