The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …

Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …

Schizophrenia is associated with substantial unmet needs, highlighting the necessity for
new treatments. This narrative review compares the pharmacology, clinical trial data and …

Schizophrenia is a serious mental illness that requires continuous and effective long-term
management to reduce symptoms, improve quality of life, and prevent relapse. Oral …

Accurate prognostication of individuals at clinical high-risk for psychosis (CHR-P) is an
essential initial step for effective primary indicated prevention. We aimed to summarise the …

Psychotic disorders affect 3% of the population at some stage in life, are a leading cause of
disability, and impose a great economic burden on society. Major breakthroughs in the …

Abstract Objective Duration of Untreated Psychosis (DUP) remains unacceptably long and
limits effectiveness of care. To determine whether an early detection campaign (“Mindmap”) …

Mounting evidence implicates microRNAs (miRNAs) in the pathology of schizophrenia.
These small noncoding RNAs bind to mRNAs containing complementary sequences and …

As employment and relationship status are important long-term outcomes in individuals with
a diagnosis of first episode psychosis (FEP) disorders, there is a need to elucidate more …

Duration of untreated psychosis (DUP) has been associated with poor mental health
outcomes. We aimed to meta-analytically estimate the mean and median DUP worldwide …