This paper presents an overview of recent advances in understanding the role of the
amorphous state in the physical and chemical transformations of pharmaceutical materials …

Despite much effort in the area, no comprehensive understanding of the formation and
behaviour of amorphous solids has yet been achieved. This severely limits the industrial …

High-temperature metastable phases exhibit superior characteristics compared to those of
thermodynamically stable phases at room temperature. Although optimization of the …

The molecules at the surface of a liquid have different organization and dynamics from those
in the bulk, potentially altering the rate of crystal nucleation and polymorphic selection, but …

There is a controversy about the extent to which the primary and secondary dielectric
relaxations influence the crystallization of amorphous organic compounds below the glass …

Compared to their crystalline forms, amorphous pharmaceutical solids present marvelous
potential and advantages for effectively improving the oral bioavailability of poorly water …

Molecules at a liquid/vapor interface have different organizations and mobilities from those
in the bulk. These differences potentially influence the rate of crystal nucleation, but the …

Amorphous solid dispersions (ASDs) are important formulation strategies for improving the
dissolution process and oral bioavailability of poorly soluble drugs. Physical stability of a …

Non-isothermal differential scanning calorimetry (DSC) was used to study the influences of
particle size (daver) and heating rate (q+) on the structural relaxation, crystal growth and …

Amorphous pharmaceutical solids (APS) are single-or multi-component systems in which
drugs exist in high-energy states with long-range disordered molecular packing. APSs have …