FN1 encoding fibronectin as a pivotal signaling gene for therapeutic intervention against pancreatic cancer

G Ashok, SK Miryala, MT Saju, A Anbarasu… - Molecular Genetics and …, 2022 - Springer
The delayed diagnosis of pancreatic cancer has resulted in rising mortality rate and low
survival rate that can be circumvented using potent theranostics biomarkers. The treatment …

Development of prognostic model incorporating a ferroptosis/cuproptosis-related signature and mutational landscape analysis in muscle-invasive bladder cancer

S Hao, Z Yang, G Wang, G Cai, Y Qin - BMC cancer, 2024 - Springer
Background Muscle-invasive bladder cancer (MIBC) is a prevalent and aggressive
malignancy. Ferroptosis and cuproptosis are recently discovered forms of programmed cell …

Bioinformatics analysis discovers microtubular tubulin beta 6 class V (TUBB6) as a potential therapeutic target in glioblastoma

L Jiang, X Zhu, H Yang, T Chen, K Lv - Frontiers in Genetics, 2020 - frontiersin.org
Glioblastoma (GBM) has long been a major clinical research challenge to scientists. The
pivotal role of the mitochondria related gene family in the promotion of GBM tumorigenesis is …

[HTML][HTML] Pan-cancer analysis of the developmental pathways reveals non-canonical wnt signaling as a driver of mesenchymal-type tumors

AG Xue, M Chan, TS Gujral - Translational Research, 2020 - Elsevier
The processes of angiogenesis, cell proliferation, invasion, and migration, and the signaling
pathways that drive these events, are activated in both cancer and during embryonic …

A comprehensive integrated gene network construction to explore the essential role of Notch 1 in lung adenocarcinoma (LUAD)

P John, C Sudandiradoss - Journal of Biomolecular Structure and …, 2024 - Taylor & Francis
The heterogeneous biological landscape of non-small cell lung cancer (NSCLC) is largely
attributed to the activation of Notch signalling pathway. Among the Notch family …

Silencing of Testin expression is a frequent event in spontaneous lymphomas from Trp53-mutant mice

RJ Weeks, JL Ludgate, G Le Mée, R Khanal… - Scientific Reports, 2020 - nature.com
The tumour suppressor gene, TES, is frequently methylated in many human tumours.
Previously, we demonstrated that TES promoter methylation and transcriptional silencing …

Survey of main tools for querying and analyzing tcga data

M Settino, M Cannataro - 2018 IEEE International Conference …, 2018 - ieeexplore.ieee.org
The development of high-throughput methods for genome interrogation, such as microarrays
and next-generation sequencing (NGS) has led to significant progress in the field of cancer …

In Silico Post Translational Analysis of Functional Single Nucleotide Alterations in Human TERT Gene Associated with Acute Myeloid Leukemia

A Munir, AM Akram, K Jamil, A Tahir - Pakistan BioMedical Journal, 2023 - pakistanbmj.com
Acute myeloid leukemia (AML) refers to a diverse assemblage of hematological
malignancies that constitute clonal expansion of immature myeloid progenitor cells in the …

[PDF][PDF] Understanding p53 in Cancer: The characteristics of uncommon TP53 missense mutations

J Patel - 2021 - ourarchive.otago.ac.nz
First, I would like to say an enormous thank you to my supervisor, Dr. Sunali Mehta, for being
an incredibly supportive supervisor and friend. You welcomed me to the world of scientific …