The emergence of ketamine as a novel treatment for posttraumatic stress disorder
A serious lack of effective pharmacotherapeutic interventions for posttraumatic stress
disorder (PTSD) raises the urgent need for the development of novel treatments. Ketamine …
disorder (PTSD) raises the urgent need for the development of novel treatments. Ketamine …
Pharmacological strategies for post-traumatic stress disorder (PTSD): From animal to clinical studies
A Gasparyan, D Navarro, F Navarrete… - Neuropharmacology, 2022 - Elsevier
Post-traumatic stress disorder (PTSD) is a disabling psychiatric condition with a critical
familiar, personal, and social impact. Patients diagnosed with PTSD show various …
familiar, personal, and social impact. Patients diagnosed with PTSD show various …
Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression
CA Farmer, JR Gilbert, R Moaddel, J George… - …, 2020 - nature.com
A single, subanesthetic dose of (R, S)-ketamine (ketamine) exerts rapid and robust
antidepressant effects. Several groups previously reported that (2S, 6S; 2R, 6R) …
antidepressant effects. Several groups previously reported that (2S, 6S; 2R, 6R) …
Ketamine in the treatment of obsessive-compulsive disorder: a systematic review
ID Bandeira, DH Lins-Silva, VB Cavenaghi… - Harvard review of …, 2022 - journals.lww.com
Methods This systematic review aims to investigate the effects of ketamine in OCD, following
the Preferred Reporting Items for Systematic Review and Meta-analyses Protocols (PRISMA …
the Preferred Reporting Items for Systematic Review and Meta-analyses Protocols (PRISMA …
Effects of an intravenous ketamine infusion on inflammatory cytokine levels in male and female Sprague–Dawley rats
Background Ketamine, a multimodal dissociative anesthetic drug, is widely used as an
analgesic following traumatic injury. Although ketamine may produce anti-inflammatory …
analgesic following traumatic injury. Although ketamine may produce anti-inflammatory …
On making (and turning adaptive to) maladaptive aversive memories in laboratory rodents
Fear conditioning and avoidance tasks usually elicit adaptive aversive memories. Traumatic
memories are more intense, generalized, inflexible, and resistant to attenuation via …
memories are more intense, generalized, inflexible, and resistant to attenuation via …
Therapeutic challenges of post-traumatic stress disorder: focus on the dopaminergic system
Post-traumatic stress disorder (PTSD) is a mental illness developed by vulnerable
individuals exposed to life-threatening events. The pharmacological unresponsiveness …
individuals exposed to life-threatening events. The pharmacological unresponsiveness …
Sex-specific effects of social isolation stress and ketamine on hippocampal plasticity
Chronic social isolation stress (SIS) induces lasting negative effects on the brain, including
memory deficits, cognitive impairments, and mood alterations such as depression and …
memory deficits, cognitive impairments, and mood alterations such as depression and …
[HTML][HTML] Ketamine beyond anesthesia: Antidepressant effects and abuse potential
KA Trujillo, SD Iñiguez - Behavioural brain research, 2020 - ncbi.nlm.nih.gov
Ketamine was first synthesized in the early 1960s in search for anesthetic compounds and
has been a mainstay for anesthesia since its approval by the United States Food and Drug …
has been a mainstay for anesthesia since its approval by the United States Food and Drug …
The role of mGluR5 on the therapeutic effects of ketamine in Wistar rats
Rationale Ketamine produces dissociative, psychomimetic, anxiolytic, antidepressant, and
anesthetic effects in a dose dependent manner. It has a complex mechanism of action that …
anesthetic effects in a dose dependent manner. It has a complex mechanism of action that …